Ariel Roldan

Montreal, QC, Canada

Last Updated: 09/26/2026

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Found 16 publications

Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain-domain coupling.

Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain-domain coupling.

Journal: bioRxiv : the preprint server for biology
Published: October 31, 2023

Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain-domain coupling.

Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain-domain coupling.

Journal: Nature communications
Published: November 16, 2022

Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes.

Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes.

Journal: iScience
Published: July 08, 2021

Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination.

Allosteric folding correction of F508del and rare CFTR mutants by elexacaftor-tezacaftor-ivacaftor (Trikafta) combination.

Journal: JCI insight
Published: May 06, 2020

Differential Scanning Fluorimetry and Hydrogen Deuterium Exchange Mass Spectrometry to Monitor the Conformational Dynamics of NBD1 in Cystic Fibrosis.

Differential Scanning Fluorimetry and Hydrogen Deuterium Exchange Mass Spectrometry to Monitor the Conformational Dynamics of NBD1 in Cystic Fibrosis.

Journal: Methods in molecular biology (Clifton, N.J.)
Published: October 21, 2018

ΔF508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter.

ΔF508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter.

Journal: SLAS discovery : advancing life sciences R & D
Published: March 14, 2018

Structure-guided combination therapy to potently improve the function of mutant CFTRs.

Structure-guided combination therapy to potently improve the function of mutant CFTRs.

Journal: Nature medicine
Published: August 28, 2017

Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell.

Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell.

Journal: Nature communications
Published: September 15, 2016

New insights into interactions between the nucleotide-binding domain of CFTR and keratin 8.

New insights into interactions between the nucleotide-binding domain of CFTR and keratin 8.

Journal: Protein science : a publication of the Protein Society
Published: July 06, 2016

Development and characterization of synthetic antibodies binding to the cystic fibrosis conductance regulator.

Development and characterization of synthetic antibodies binding to the cystic fibrosis conductance regulator.

Journal: mAbs
Published: May 18, 2016

Rattlesnake Phospholipase A2 Increases CFTR-Chloride Channel Current and Corrects ∆F508CFTR Dysfunction: Impact in Cystic Fibrosis.

Rattlesnake Phospholipase A2 Increases CFTR-Chloride Channel Current and Corrects ∆F508CFTR Dysfunction: Impact in Cystic Fibrosis.

Journal: Journal of molecular biology
Published: March 04, 2016

Non-native Conformers of Cystic Fibrosis Transmembrane Conductance Regulator NBD1 Are Recognized by Hsp27 and Conjugated to SUMO-2 for Degradation.

Non-native Conformers of Cystic Fibrosis Transmembrane Conductance Regulator NBD1 Are Recognized by Hsp27 and Conjugated to SUMO-2 for Degradation.

Journal: The Journal of biological chemistry
Published: August 19, 2015
Showing 1-12 of 16

Last Updated: 09/26/2026