Last Updated: 09/26/2026
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Found 24 publications
M1 receptor positive allosteric modulators discovery approaches.
Journal: Trends in pharmacological sciences
Published: February 03, 2025
Population Pharmacokinetic and Exposure-Response Analysis of the Cognitive Effects of TAK-071 in Participants With Parkinson Disease and Cognitive Impairment.
Journal: Clinical pharmacology in drug development
Published: January 31, 2025
An Acetylcholine M1 Receptor-Positive Allosteric Modulator (TAK-071) in Parkinson Disease With Cognitive Impairment: A Phase 2 Randomized Clinical Trial.
Journal: JAMA neurology
Published: January 06, 2025
Phase 1, randomized trials of MEDI1341: cerebrospinal fluid free α-synuclein lowered by >50.
Journal: Brain communications
Published: December 03, 2024
Temporal progression of tau pathology and neuroinflammation in a rhesus monkey model of Alzheimer's disease.
Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association
Published: January 17, 2024
Identifying individuals with non-Alzheimer's disease co-pathologies: A precision medicine approach to clinical trials in sporadic Alzheimer's disease.
Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association
Published: May 09, 2023
Investigation of genetic determinants of cognitive change in later life.
Journal: Translational psychiatry
Published: April 14, 2023
Safety, pharmacokinetics and quantitative EEG modulation of TAK-071, a novel muscarinic M1 receptor positive allosteric modulator, in healthy subjects.
Journal: British journal of clinical pharmacology
Published: February 08, 2021
An 8-Week, Randomized, Phase 2, Double-Blind, Sequential Parallel-Group Comparison Study of Two Dose Levels of the GABAA Positive Allosteric Modulator PF-06372865 Compared With Placebo as an Adjunctive Treatment in Outpatients With Inadequate Response to Standard of Care for Generalized Anxiety Disorder.
Journal: Journal of clinical psychopharmacology
Published: December 12, 2018
Audio Recording for Independent Confirmation of Clinical Assessments in Generalized Anxiety Disorder.
Journal: Innovations in clinical neuroscience
Published: May 04, 2018
The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect.
Journal: Behavioural brain research
Published: March 08, 2016
A randomized, crossover, placebo-controlled clinical trial to assess the sensitivity of the CRCDS Mini-Sim to the next-day residual effects of zopiclone.
Journal: Therapeutic advances in drug safety
Published: August 05, 2015
Last Updated: 09/26/2026