Ashleigh S. Paparella

Adelaide, SA 5005, Australia

Last Updated: 09/26/2026

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Found 14 publications

Isofagomine Derivatives as TcdB Glucosyltransferase Inhibitors.

Isofagomine Derivatives as TcdB Glucosyltransferase Inhibitors.

Journal: Journal of medicinal chemistry

Published: July 01, 2026

First inhibitor of a bacterial two-partner secretion system.

First inhibitor of a bacterial two-partner secretion system.

Journal: bioRxiv : the preprint server for biology

Published: February 06, 2026

Isofagomine Inhibits Multiple TcdB Variants and Protects Mice from Clostridioides difficile-Induced Mortality.

Isofagomine Inhibits Multiple TcdB Variants and Protects Mice from Clostridioides difficile-Induced Mortality.

Journal: ACS infectious diseases

Published: February 09, 2024

Isofagomine inhibits multiple TcdB variants and protects mice from Clostridioides difficile induced mortality.

Isofagomine inhibits multiple TcdB variants and protects mice from Clostridioides difficile induced mortality.

Journal: bioRxiv : the preprint server for biology

Published: October 02, 2023

Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an SNi Mechanism and Ion Pair Transition State.

Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an SNi Mechanism and Ion Pair Transition State.

Journal: ACS chemical biology

Published: August 29, 2022

Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues.

Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues.

Journal: Nature communications

Published: April 13, 2021

Advanced Resistance Studies Identify Two Discrete Mechanisms in Staphylococcus aureus to Overcome Antibacterial Compounds that Target Biotin Protein Ligase.

Advanced Resistance Studies Identify Two Discrete Mechanisms in Staphylococcus aureus to Overcome Antibacterial Compounds that Target Biotin Protein Ligase.

Journal: Antibiotics (Basel, Switzerland)

Published: March 23, 2020

Sulfonamide-Based Inhibitors of Biotin Protein Ligase as New Antibiotic Leads.

Sulfonamide-Based Inhibitors of Biotin Protein Ligase as New Antibiotic Leads.

Journal: ACS chemical biology

Published: August 14, 2019

Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus.

Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus.

Journal: ACS infectious diseases

Published: November 14, 2017

New Series of BPL Inhibitors To Probe the Ribose-Binding Pocket of Staphylococcus aureus Biotin Protein Ligase.

New Series of BPL Inhibitors To Probe the Ribose-Binding Pocket of Staphylococcus aureus Biotin Protein Ligase.

Journal: ACS medicinal chemistry letters

Published: June 26, 2016

Biotin Protein Ligase Is a Target for New Antibacterials.

Biotin Protein Ligase Is a Target for New Antibacterials.

Journal: Antibiotics (Basel, Switzerland)

Published: June 15, 2016

Improved Synthesis of Biotinol-5'-AMP: Implications for Antibacterial Discovery.

Improved Synthesis of Biotinol-5'-AMP: Implications for Antibacterial Discovery.

Journal: ACS medicinal chemistry letters

Published: November 20, 2014

Showing 1-12 of 14

Last Updated: 09/26/2026