Ashley Hutchinson

Toronto, ON, Canada

Last Updated: 09/26/2026

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Found 26 publications

Hepatocyte growth factor activator inhibitor-2 rapidly inactivates airway-expressed human Type II Transmembrane Serine Proteases.

Hepatocyte growth factor activator inhibitor-2 rapidly inactivates airway-expressed human Type II Transmembrane Serine Proteases.

Journal: The Journal of biological chemistry

Published: February 05, 2026

CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2.

CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2.

Journal: Journal of chemical information and modeling

Published: January 21, 2026

Structure-based discovery of inhibitors of Mac1 domain of nonstructural protein-3 of SARS-CoV-2 by machine learning-augmented screening of chemical space.

Structure-based discovery of inhibitors of Mac1 domain of nonstructural protein-3 of SARS-CoV-2 by machine learning-augmented screening of chemical space.

Journal: bioRxiv : the preprint server for biology

Published: September 18, 2025

CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13.

CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13.

Journal: Journal of chemical information and modeling

Published: June 20, 2025

Active Learning-Guided Hit Optimization for the Leucine-Rich Repeat Kinase 2 WDR Domain Based on In Silico Ligand-Binding Affinities.

Active Learning-Guided Hit Optimization for the Leucine-Rich Repeat Kinase 2 WDR Domain Based on In Silico Ligand-Binding Affinities.

Journal: Journal of chemical information and modeling

Published: May 26, 2025

Functionally active modulators targeting the LRRK2 WD40 repeat domain identified by FRASE-bot in CACHE Challenge #1.

Functionally active modulators targeting the LRRK2 WD40 repeat domain identified by FRASE-bot in CACHE Challenge #1.

Journal: Chemical science

Published: November 07, 2024

A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins.

A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins.

Journal: Journal of medicinal chemistry

Published: November 04, 2024

Correction to "Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials".

Correction to "Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials".

Journal: Journal of medicinal chemistry

Published: July 10, 2024

Subpocket Similarity-Based Hit Identification for Challenging Targets: Application to the WDR Domain of LRRK2.

Subpocket Similarity-Based Hit Identification for Challenging Targets: Application to the WDR Domain of LRRK2.

Journal: Journal of chemical information and modeling

Published: June 25, 2024

Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials.

Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials.

Journal: Journal of medicinal chemistry

Published: February 19, 2024

Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning.

Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning.

Journal: Journal of medicinal chemistry

Published: November 23, 2023

Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40.

Delineation of functional subdomains of Huntingtin protein and their interaction with HAP40.

Journal: Structure (London, England : 1993)

Published: January 26, 2023

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Last Updated: 09/26/2026