Ashwini M. Londhe

Seoul, Republic of Korea

Last Updated: 09/26/2026

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Found 14 publications

Highly potent and selective PPARδ agonist reverses memory deficits in mouse models of Alzheimer's disease.

Highly potent and selective PPARδ agonist reverses memory deficits in mouse models of Alzheimer's disease.

Journal: Theranostics

Published: March 28, 2024

Modulation of SETDB1 activity by APQ ameliorates heterochromatin condensation, motor function, and neuropathology in a Huntington's disease mouse model.

Modulation of SETDB1 activity by APQ ameliorates heterochromatin condensation, motor function, and neuropathology in a Huntington's disease mouse model.

Journal: Journal of enzyme inhibition and medicinal chemistry

Published: March 27, 2021

The translocator protein ligands as mitochondrial functional modulators for the potential anti-Alzheimer agents.

The translocator protein ligands as mitochondrial functional modulators for the potential anti-Alzheimer agents.

Journal: Journal of enzyme inhibition and medicinal chemistry

Published: March 23, 2021

Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B.

Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B.

Journal: Journal of enzyme inhibition and medicinal chemistry

Published: August 06, 2020

Nrf2 activator via interference of Nrf2-Keap1 interaction has antioxidant and anti-inflammatory properties in Parkinson's disease animal model.

Nrf2 activator via interference of Nrf2-Keap1 interaction has antioxidant and anti-inflammatory properties in Parkinson's disease animal model.

Journal: Neuropharmacology

Published: September 17, 2019

Investigation of Molecular Details of Keap1-Nrf2 Inhibitors Using Molecular Dynamics and Umbrella Sampling Techniques.

Investigation of Molecular Details of Keap1-Nrf2 Inhibitors Using Molecular Dynamics and Umbrella Sampling Techniques.

Journal: Molecules (Basel, Switzerland)

Published: September 07, 2019

Synthesis and Biological Evaluation of Disubstituted Pyrimidines as Selective 5-HT2C Agonists.

Synthesis and Biological Evaluation of Disubstituted Pyrimidines as Selective 5-HT2C Agonists.

Journal: Molecules (Basel, Switzerland)

Published: August 01, 2019

CRISPR-mediated gene correction links the ATP7A M1311V mutations with amyotrophic lateral sclerosis pathogenesis in one individual.

CRISPR-mediated gene correction links the ATP7A M1311V mutations with amyotrophic lateral sclerosis pathogenesis in one individual.

Journal: Communications biology

Published: April 01, 2019

Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer's disease.

Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer's disease.

Journal: Science advances

Published: August 07, 2018

Synthesis and evaluation of an orally available "Y"-shaped biaryl peroxisome proliferator-activated receptor δ agonist.

Synthesis and evaluation of an orally available "Y"-shaped biaryl peroxisome proliferator-activated receptor δ agonist.

Journal: Bioorganic & medicinal chemistry

Published: May 10, 2018

In silico probing and biological evaluation of SETDB1/ESET-targeted novel compounds that reduce tri-methylated histone H3K9 (H3K9me3) level.

In silico probing and biological evaluation of SETDB1/ESET-targeted novel compounds that reduce tri-methylated histone H3K9 (H3K9me3) level.

Journal: Journal of computer-aided molecular design

Published: April 28, 2017

Discovery of non-peptidic small molecule inhibitors of cyclophilin D as neuroprotective agents in Aβ-induced mitochondrial dysfunction.

Discovery of non-peptidic small molecule inhibitors of cyclophilin D as neuroprotective agents in Aβ-induced mitochondrial dysfunction.

Journal: Journal of computer-aided molecular design

Published: April 27, 2017

Showing 1-12 of 14

Last Updated: 09/26/2026