Ayako Moritomo

R&D Division, 1-2-58 Hiromachi, Shinagawa Ku
Hiromachi, 1408710, Japan

Last Updated: 09/26/2026

Save publications for later

Sign Up

Not sure about your diagnosis?

Check Your Symptoms

Found 25 publications

Structure-based design, synthesis, and evaluation of tetrahydrotriazolothiazepine derivatives as novel 11β-hydroxysteroid dehydrogenase type 1 inhibitors.

Structure-based design, synthesis, and evaluation of tetrahydrotriazolothiazepine derivatives as novel 11β-hydroxysteroid dehydrogenase type 1 inhibitors.

Journal: Bioorganic & medicinal chemistry

Published: August 05, 2025

Analysis of fluoroquinolone-resistance using MIC determination and homology modelling of ParC of contemporary Mycoplasma genitalium strains.

Analysis of fluoroquinolone-resistance using MIC determination and homology modelling of ParC of contemporary Mycoplasma genitalium strains.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

Published: May 03, 2021

Discovery and Biological Evaluation of Potent and Orally Active Human 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors for the Treatment of Type 2 Diabetes Mellitus.

Discovery and Biological Evaluation of Potent and Orally Active Human 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors for the Treatment of Type 2 Diabetes Mellitus.

Journal: Chemical & pharmaceutical bulletin

Published: August 02, 2019

Synthesis and structure-activity relationships of pyrazine-2-carboxamide derivatives as novel echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) inhibitors.

Synthesis and structure-activity relationships of pyrazine-2-carboxamide derivatives as novel echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) inhibitors.

Journal: Bioorganic & medicinal chemistry

Published: January 27, 2019

Optimization of 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidines to generate a highly selective PI3Kδ inhibitor.

Optimization of 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidines to generate a highly selective PI3Kδ inhibitor.

Journal: Bioorganic & medicinal chemistry

Published: January 09, 2019

Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor.

Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor.

Journal: Bioorganic & medicinal chemistry

Published: July 20, 2018

Optimization and in vivo evaluation of pyrazolopyridines as a potent and selective PI3Kδ inhibitor.

Optimization and in vivo evaluation of pyrazolopyridines as a potent and selective PI3Kδ inhibitor.

Journal: Bioorganic & medicinal chemistry

Published: April 27, 2018

Discovery and biological evaluation of novel pyrazolopyridine derivatives as potent and orally available PI3Kδ inhibitors.

Discovery and biological evaluation of novel pyrazolopyridine derivatives as potent and orally available PI3Kδ inhibitors.

Journal: Bioorganic & medicinal chemistry

Published: March 01, 2018

Discovery of tricyclic dipyrrolopyridine derivatives as novel JAK inhibitors.

Discovery of tricyclic dipyrrolopyridine derivatives as novel JAK inhibitors.

Journal: Bioorganic & medicinal chemistry

Published: July 07, 2017

Corrigendum to "Synthesis and evaluation of novel 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives as potent and orally efficacious immunomodulators targeting JAK3" [Bioorg. Med. Chem. 23 (2015) 4871-4883].

Corrigendum to "Synthesis and evaluation of novel 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives as potent and orally efficacious immunomodulators targeting JAK3" [Bioorg. Med. Chem. 23 (2015) 4871-4883].

Journal: Bioorganic & medicinal chemistry

Published: April 04, 2017

Synthesis and pharmacological evaluation of glycine amide derivatives as novel vascular adhesion protein-1 inhibitors without CYP3A4 and CYP2C19 inhibition.

Synthesis and pharmacological evaluation of glycine amide derivatives as novel vascular adhesion protein-1 inhibitors without CYP3A4 and CYP2C19 inhibition.

Journal: Bioorganic & medicinal chemistry

Published: March 02, 2017

Synthesis and structure activity relationships of glycine amide derivatives as novel Vascular Adhesion Protein-1 inhibitors.

Synthesis and structure activity relationships of glycine amide derivatives as novel Vascular Adhesion Protein-1 inhibitors.

Journal: Bioorganic & medicinal chemistry

Published: September 20, 2016

Showing 1-12 of 25

Last Updated: 09/26/2026