Aycha J. Bleeker

Groningen, GR, Netherlands

Last Updated: 09/26/2026

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Found 16 publications

Hepatocyte-specific Cas9-mediated editing of G6pc and Slc37a4 elicits comparable biochemical and regulatory responses between glycogen storage disease (GSD) type Ia and Ib mice.

Hepatocyte-specific Cas9-mediated editing of G6pc and Slc37a4 elicits comparable biochemical and regulatory responses between glycogen storage disease (GSD) type Ia and Ib mice.

Journal: Molecular metabolism

Published: October 24, 2025

Untargeted Proteomics Profiling of Liver and Plasma in Fed and Fasted Liver-Specific Glycogen Storage Disease Type Ia (GSD Ia) Mice: Toward Potential Protein Biomarkers.

Untargeted Proteomics Profiling of Liver and Plasma in Fed and Fasted Liver-Specific Glycogen Storage Disease Type Ia (GSD Ia) Mice: Toward Potential Protein Biomarkers.

Journal: Journal of inherited metabolic disease

Published: April 24, 2025

Endogenous Glucose Production in Patients With Glycogen Storage Disease Type Ia Estimated by Oral D-[6,6-2H2]-glucose.

Endogenous Glucose Production in Patients With Glycogen Storage Disease Type Ia Estimated by Oral D-[6,6-2H2]-glucose.

Journal: The Journal of clinical endocrinology and metabolism

Published: April 04, 2023

Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia.

Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia.

Journal: Cancer & metabolism

Published: January 25, 2023

Identification of emerging safety and sustainability issues of advanced materials: Proposal for a systematic approach.

Identification of emerging safety and sustainability issues of advanced materials: Proposal for a systematic approach.

Journal: NanoImpact

Published: April 07, 2021

Impaired Very-Low-Density Lipoprotein catabolism links hypoglycemia to hypertriglyceridemia in Glycogen Storage Disease type Ia.

Impaired Very-Low-Density Lipoprotein catabolism links hypoglycemia to hypertriglyceridemia in Glycogen Storage Disease type Ia.

Journal: Journal of inherited metabolic disease

Published: September 07, 2020

Hepatic Carbohydrate Response Element Binding Protein Activation Limits Nonalcoholic Fatty Liver Disease Development in a Mouse Model for Glycogen Storage Disease Type 1a.

Hepatic Carbohydrate Response Element Binding Protein Activation Limits Nonalcoholic Fatty Liver Disease Development in a Mouse Model for Glycogen Storage Disease Type 1a.

Journal: Hepatology (Baltimore, Md.)

Published: July 05, 2019

Running wheel access fails to resolve impaired sustainable health in mice feeding a high fat sucrose diet.

Running wheel access fails to resolve impaired sustainable health in mice feeding a high fat sucrose diet.

Journal: Aging

Published: October 08, 2018

Insights into possibilities for grouping and read-across for nanomaterials in EU chemicals legislation.

Insights into possibilities for grouping and read-across for nanomaterials in EU chemicals legislation.

Journal: Nanotoxicology

Published: September 06, 2018

Glucose-6-Phosphate Regulates Hepatic Bile Acid Synthesis in Mice.

Glucose-6-Phosphate Regulates Hepatic Bile Acid Synthesis in Mice.

Journal: Hepatology (Baltimore, Md.)

Published: August 27, 2018

Living on the edge: substrate competition explains loss of robustness in mitochondrial fatty-acid oxidation disorders.

Living on the edge: substrate competition explains loss of robustness in mitochondrial fatty-acid oxidation disorders.

Journal: BMC biology

Published: July 15, 2016

Protection against the Metabolic Syndrome by Guar Gum-Derived Short-Chain Fatty Acids Depends on Peroxisome Proliferator-Activated Receptor γ and Glucagon-Like Peptide-1.

Protection against the Metabolic Syndrome by Guar Gum-Derived Short-Chain Fatty Acids Depends on Peroxisome Proliferator-Activated Receptor γ and Glucagon-Like Peptide-1.

Journal: PloS one

Published: April 28, 2015

Showing 1-12 of 16

Last Updated: 09/26/2026