Ayman E. Sahar-El

Kasr El Aini Street
Cairo, C 11562, Egypt

Last Updated: 09/26/2026

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Found 30 publications

Unveiling Remyelinating Properties of Roflumilast in CPZ-Induced Neuronal Demyelination in Mice.

Unveiling Remyelinating Properties of Roflumilast in CPZ-Induced Neuronal Demyelination in Mice.

Journal: Drug development research

Published: December 27, 2025

The protective effect of febuxostat in a rotenone mouse model of Parkinson's disease: the interplay between PI3K/Akt/mTOR, GSK-3β, and Nrf2/HO-1 signaling pathways.

The protective effect of febuxostat in a rotenone mouse model of Parkinson's disease: the interplay between PI3K/Akt/mTOR, GSK-3β, and Nrf2/HO-1 signaling pathways.

Journal: The Journal of pharmacy and pharmacology

Published: November 16, 2025

Liraglutide orchestrates ferroptosis defense against murine cisplatin acute kidney injury: NRF2 activation via both KEAP1-dependent and -independent mechanisms is essential for SLC7A11/GPX4 renoprotection.

Liraglutide orchestrates ferroptosis defense against murine cisplatin acute kidney injury: NRF2 activation via both KEAP1-dependent and -independent mechanisms is essential for SLC7A11/GPX4 renoprotection.

Journal: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

Published: June 25, 2025

The Role of the AMY1 Receptor Signaling Cascade in the Protective Effect of Sulforaphane Against Nitroglycerin-Induced Migraine in Mice.

The Role of the AMY1 Receptor Signaling Cascade in the Protective Effect of Sulforaphane Against Nitroglycerin-Induced Migraine in Mice.

Journal: Archiv der Pharmazie

Published: April 16, 2025

Ameliorative effect of palonosetron against binge alcohol-induced neurodamage via targeting miR-155/AKT/mTOR/AMPK-mediated autophagic pathway.

Ameliorative effect of palonosetron against binge alcohol-induced neurodamage via targeting miR-155/AKT/mTOR/AMPK-mediated autophagic pathway.

Journal: Archives of biochemistry and biophysics

Published: March 22, 2025

Dipeptidyl peptidase-4 enzyme inhibition and its impacts on hepatic preneoplasia: a new avenue for liver cancer management.

Dipeptidyl peptidase-4 enzyme inhibition and its impacts on hepatic preneoplasia: a new avenue for liver cancer management.

Journal: Frontiers in pharmacology

Published: January 14, 2025

TLR-4/Notch1/NF-κB pathway modulation by dapagliflozin: a novel mechanism for neuroprotection in hepatic encephalopathy.

TLR-4/Notch1/NF-κB pathway modulation by dapagliflozin: a novel mechanism for neuroprotection in hepatic encephalopathy.

Journal: Metabolic brain disease

Published: December 12, 2024

Ascorbic acid Mitigates behavioural disturbances associated with letrozole-induced PCOS via switching-off JAK2/STAT5 and JAK2/ERK1/2 pathways in rat hippocampus.

Ascorbic acid Mitigates behavioural disturbances associated with letrozole-induced PCOS via switching-off JAK2/STAT5 and JAK2/ERK1/2 pathways in rat hippocampus.

Journal: Steroids

Published: September 10, 2024

Repurposing ezetimibe as a neuroprotective agent in a rotenone-induced Parkinson's disease model in rats: Role of AMPK/SIRT-1/PGC-1α signaling and autophagy.

Repurposing ezetimibe as a neuroprotective agent in a rotenone-induced Parkinson's disease model in rats: Role of AMPK/SIRT-1/PGC-1α signaling and autophagy.

Journal: International immunopharmacology

Published: May 29, 2024

Empagliflozin Dampens Doxorubicin-Induced Chemobrain in Rats: The Possible Involvement of Oxidative Stress and PI3K/Akt/mTOR/NF-κB/TNF-α Signaling Pathways.

Empagliflozin Dampens Doxorubicin-Induced Chemobrain in Rats: The Possible Involvement of Oxidative Stress and PI3K/Akt/mTOR/NF-κB/TNF-α Signaling Pathways.

Journal: Molecular neurobiology

Published: March 16, 2024

Unleashing lactoferrin's antidepressant potential through the PI3K/Akt/mTOR pathway in chronic restraint stress rats.

Unleashing lactoferrin's antidepressant potential through the PI3K/Akt/mTOR pathway in chronic restraint stress rats.

Journal: Food & function

Published: September 28, 2023

Lactoferrin averts neurological and behavioral impairments of thioacetamide-induced hepatic encephalopathy in rats via modulating HGMB1/TLR-4/MyD88/Nrf2 pathway.

Lactoferrin averts neurological and behavioral impairments of thioacetamide-induced hepatic encephalopathy in rats via modulating HGMB1/TLR-4/MyD88/Nrf2 pathway.

Journal: Neuropharmacology

Published: February 28, 2023

Showing 1-12 of 30

Last Updated: 09/26/2026