Aytug K. Kiper

Marburg An Der Lahn, HE, Germany

Last Updated: 09/26/2026

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Found 31 publications

The TASK-1 and TASK-3 activator JG-C3-98 attenuates cold and mechanical responses in primary somatosensory neurons.

The TASK-1 and TASK-3 activator JG-C3-98 attenuates cold and mechanical responses in primary somatosensory neurons.

Journal: Frontiers in pharmacology

Published: March 31, 2026

Rational design, synthesis, and evaluation of novel polypharmacological compounds targeting NaV1.5, KV1.5, and K2P channels for atrial fibrillation.

Rational design, synthesis, and evaluation of novel polypharmacological compounds targeting NaV1.5, KV1.5, and K2P channels for atrial fibrillation.

Journal: The Journal of biological chemistry

Published: July 20, 2024

KCNQ1 is an essential mediator of the sex-dependent perception of moderate cold temperatures.

KCNQ1 is an essential mediator of the sex-dependent perception of moderate cold temperatures.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: June 10, 2024

Potassium channel TASK-5 forms functional heterodimers with TASK-1 and TASK-3 to break its silence.

Potassium channel TASK-5 forms functional heterodimers with TASK-1 and TASK-3 to break its silence.

Journal: Nature communications

Published: May 31, 2024

Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K2P channel TALK-2.

Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K2P channel TALK-2.

Journal: Nature communications

Published: November 23, 2023

Popeye domain containing proteins modulate the voltage-gated cardiac sodium channel Nav1.5.

Popeye domain containing proteins modulate the voltage-gated cardiac sodium channel Nav1.5.

Journal: iScience

Published: September 25, 2023

Calcium Handling Remodeling Underlies Impaired Sympathetic Stress Response in Ventricular Myocardium from Cacna1c Haploinsufficient Rats.

Calcium Handling Remodeling Underlies Impaired Sympathetic Stress Response in Ventricular Myocardium from Cacna1c Haploinsufficient Rats.

Journal: International journal of molecular sciences

Published: April 26, 2023

Cloxyquin activates hTRESK by allosteric modulation of the selectivity filter.

Cloxyquin activates hTRESK by allosteric modulation of the selectivity filter.

Journal: Communications biology

Published: January 04, 2023

Selective TASK-1 Inhibitor with a Defined Structure-Activity Relationship Reduces Cancer Cell Proliferation and Viability.

Selective TASK-1 Inhibitor with a Defined Structure-Activity Relationship Reduces Cancer Cell Proliferation and Viability.

Journal: Journal of medicinal chemistry

Published: November 15, 2022

A New Strategy for Multitarget Drug Discovery/Repositioning Through the Identification of Similar 3D Amino Acid Patterns Among Proteins Structures: The Case of Tafluprost and its Effects on Cardiac Ion Channels.

A New Strategy for Multitarget Drug Discovery/Repositioning Through the Identification of Similar 3D Amino Acid Patterns Among Proteins Structures: The Case of Tafluprost and its Effects on Cardiac Ion Channels.

Journal: Frontiers in pharmacology

Published: January 16, 2022

Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson's disease.

Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson's disease.

Journal: Scientific reports

Published: November 08, 2021

5-(Indol-2-yl)pyrazolo[3,4-b]pyridines as a New Family of TASK-3 Channel Blockers: A Pharmacophore-Based Regioselective Synthesis.

5-(Indol-2-yl)pyrazolo[3,4-b]pyridines as a New Family of TASK-3 Channel Blockers: A Pharmacophore-Based Regioselective Synthesis.

Journal: Molecules (Basel, Switzerland)

Published: May 28, 2021

Showing 1-12 of 31

Last Updated: 09/26/2026