Aziza El Harchi

University Walk
Bristol, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 21 publications

Stereoselective block of the hERG potassium channel by the Class Ia antiarrhythmic drug disopyramide.

Stereoselective block of the hERG potassium channel by the Class Ia antiarrhythmic drug disopyramide.

Journal: Cellular and molecular life sciences : CMLS

Published: July 20, 2024

Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue.

Inhibition of the hERG Potassium Channel by a Methanesulphonate-Free E-4031 Analogue.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: July 28, 2023

hERG agonists pose challenges to web-based machine learning methods for prediction of drug-hERG channel interaction.

hERG agonists pose challenges to web-based machine learning methods for prediction of drug-hERG channel interaction.

Journal: Journal of pharmacological and toxicological methods

Published: February 07, 2023

Pharmacological activation of the hERG K+ channel for the management of the long QT syndrome: A review.

Pharmacological activation of the hERG K+ channel for the management of the long QT syndrome: A review.

Journal: Journal of arrhythmia

Published: February 28, 2022

COVID-19 Management and Arrhythmia: Risks and Challenges for Clinicians Treating Patients Affected by SARS-CoV-2.

COVID-19 Management and Arrhythmia: Risks and Challenges for Clinicians Treating Patients Affected by SARS-CoV-2.

Journal: Frontiers in cardiovascular medicine

Published: March 25, 2020

The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine.

The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine.

Journal: Physiological reports

Published: December 18, 2019

Structure-activity relationship and cardiac safety of 2-aryl-2-(pyridin-2-yl)acetamides as a new class of broad-spectrum anticonvulsants derived from Disopyramide.

Structure-activity relationship and cardiac safety of 2-aryl-2-(pyridin-2-yl)acetamides as a new class of broad-spectrum anticonvulsants derived from Disopyramide.

Journal: Bioorganic chemistry

Published: October 02, 2019

Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker.

Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker.

Journal: The Journal of biological chemistry

Published: October 10, 2017

In silico investigation of a KCNQ1 mutation associated with short QT syndrome.

In silico investigation of a KCNQ1 mutation associated with short QT syndrome.

Journal: Scientific reports

Published: May 08, 2017

Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria.

Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria.

Journal: PLoS computational biology

Published: March 21, 2017

Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking.

Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking.

Journal: Biochemical pharmacology

Published: April 12, 2016

hERG potassium channel inhibition by ivabradine requires channel gating.

hERG potassium channel inhibition by ivabradine requires channel gating.

Journal: Journal of molecular and cellular cardiology

Published: June 15, 2015

Showing 1-12 of 21

Last Updated: 09/26/2026