Ben Capuano

Parkville, VIC 3052, Australia

Last Updated: 09/26/2026

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Found 68 publications

The Design, Synthesis and Pharmacological Characterization of Potent Xanomeline-Based M1 and M4 mAChR Bitopic Ligands.

The Design, Synthesis and Pharmacological Characterization of Potent Xanomeline-Based M1 and M4 mAChR Bitopic Ligands.

Journal: Journal of medicinal chemistry

Published: July 27, 2026

Exploiting a Cryptic Pocket in DsbA through Structure-Guided Parallel Synthesis and Direct-to-Biology Screening.

Exploiting a Cryptic Pocket in DsbA through Structure-Guided Parallel Synthesis and Direct-to-Biology Screening.

Journal: Journal of medicinal chemistry

Published: March 06, 2026

Structure-guided allosteric modulation of the delta opioid receptor.

Structure-guided allosteric modulation of the delta opioid receptor.

Journal: bioRxiv : the preprint server for biology

Published: November 24, 2025

G Protein: β-Arrestin Bias Confers Differential Regulation of Gαq Signaling by GPR17 Antagonists.

G Protein: β-Arrestin Bias Confers Differential Regulation of Gαq Signaling by GPR17 Antagonists.

Journal: ACS chemical neuroscience

Published: November 12, 2025

A Structure-Activity Relationship Study of Novel Positive Allosteric Modulators for the δ-Opioid Receptor.

A Structure-Activity Relationship Study of Novel Positive Allosteric Modulators for the δ-Opioid Receptor.

Journal: ACS chemical neuroscience

Published: July 18, 2025

Discovery of a Cryptic Pocket in EcDsbA Opens New Opportunities for Antibacterial Discovery.

Discovery of a Cryptic Pocket in EcDsbA Opens New Opportunities for Antibacterial Discovery.

Journal: Angewandte Chemie (International ed. in English)

Published: July 14, 2025

The Prosperity and Adversity of M4 Muscarinic Acetylcholine Receptor Activators in the Treatment of Neuropsychiatric Disorders.

The Prosperity and Adversity of M4 Muscarinic Acetylcholine Receptor Activators in the Treatment of Neuropsychiatric Disorders.

Journal: Journal of medicinal chemistry

Published: April 16, 2025

Identification of an Allene Warhead That Selectively Targets a Histidine Residue in the Escherichia coli Oxidoreductase Enzyme DsbA.

Identification of an Allene Warhead That Selectively Targets a Histidine Residue in the Escherichia coli Oxidoreductase Enzyme DsbA.

Journal: ACS medicinal chemistry letters

Published: January 09, 2025

Next-Generation Analogues of AC265347 as Positive Allosteric Modulators of the Calcium-Sensing Receptor: Pharmacological Investigation of Structural Modifications at the Stereogenic Centre.

Next-Generation Analogues of AC265347 as Positive Allosteric Modulators of the Calcium-Sensing Receptor: Pharmacological Investigation of Structural Modifications at the Stereogenic Centre.

Journal: International journal of molecular sciences

Published: December 19, 2024

A novel chemoreactive calcilytic for the potential treatment of autosomal dominant hypocalcemia.

A novel chemoreactive calcilytic for the potential treatment of autosomal dominant hypocalcemia.

Journal: Acta pharmaceutica Sinica. B

Published: December 02, 2024

Discovery of 2-Methyl-5-(1H-pyrazol-4-yl)pyridines and Related Heterocycles as Promising M4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders.

Discovery of 2-Methyl-5-(1H-pyrazol-4-yl)pyridines and Related Heterocycles as Promising M4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders.

Journal: Journal of medicinal chemistry

Published: July 18, 2024

Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M4 mAChR.

Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M4 mAChR.

Journal: European journal of medicinal chemistry

Published: April 24, 2023

Showing 1-12 of 68

Last Updated: 09/26/2026