Ben D. Bax

Park Place
Cardiff, WLS CF103AT, United Kingdom

Last Updated: 09/26/2026

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Found 11 publications

Structure-based discovery of first inhibitors targeting the helicase activity of human PIF1.

Structure-based discovery of first inhibitors targeting the helicase activity of human PIF1.

Journal: Nucleic acids research

Published: June 04, 2024

A Series of Spiropyrimidinetriones that Enhances DNA Cleavage Mediated by Mycobacterium tuberculosis Gyrase.

A Series of Spiropyrimidinetriones that Enhances DNA Cleavage Mediated by Mycobacterium tuberculosis Gyrase.

Journal: ACS infectious diseases

Published: February 21, 2023

A 2.8 Å Structure of Zoliflodacin in a DNA Cleavage Complex with Staphylococcus aureus DNA Gyrase.

A 2.8 Å Structure of Zoliflodacin in a DNA Cleavage Complex with Staphylococcus aureus DNA Gyrase.

Journal: International journal of molecular sciences

Published: November 22, 2022

Oligonucleotide-Recognizing Topoisomerase Inhibitors (OTIs): Precision Gene Editors for Neurodegenerative Diseases?

Oligonucleotide-Recognizing Topoisomerase Inhibitors (OTIs): Precision Gene Editors for Neurodegenerative Diseases?

Journal: International journal of molecular sciences

Published: July 28, 2022

Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.

Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.

Journal: ACS infectious diseases

Published: February 14, 2019

Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase.

Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase.

Journal: Nucleic acids research

Published: September 27, 2018

Mechanism of Action of Mycobacterium tuberculosis Gyrase Inhibitors: A Novel Class of Gyrase Poisons.

Mechanism of Action of Mycobacterium tuberculosis Gyrase Inhibitors: A Novel Class of Gyrase Poisons.

Journal: ACS infectious diseases

Published: May 11, 2018

Coupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences.

Coupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences.

Journal: Nucleic acids research

Published: October 03, 2017

Getting the chemistry right: protonation, tautomers and the importance of H atoms in biological chemistry.

Getting the chemistry right: protonation, tautomers and the importance of H atoms in biological chemistry.

Journal: Acta crystallographica. Section D, Structural biology

Published: September 29, 2016

Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases.

Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases.

Journal: Bioorganic & medicinal chemistry letters

Published: March 03, 2016

Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases.

Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases.

Journal: Bioorganic & medicinal chemistry letters

Published: June 02, 2013

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Last Updated: 09/26/2026