Benedetta Mannini

Cambridge, ENG CB21EW, United Kingdom

Last Updated: 09/26/2026

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Found 40 publications

Structure-Activity Relationship Study of Protoberberine Alkaloids Reveals Molecular Planarity as a Key Determinant of Membrane Interaction and Protection from Misfolded Protein Oligomers.

Structure-Activity Relationship Study of Protoberberine Alkaloids Reveals Molecular Planarity as a Key Determinant of Membrane Interaction and Protection from Misfolded Protein Oligomers.

Journal: Journal of medicinal chemistry

Published: May 27, 2026

Berberine mitigates neurotoxicity of misfolded protein oligomers by interacting with the cell membrane and subsequent internalization, without altering their structure.

Berberine mitigates neurotoxicity of misfolded protein oligomers by interacting with the cell membrane and subsequent internalization, without altering their structure.

Journal: International journal of biological macromolecules

Published: June 10, 2025

Targeting Protein Aggregation in ALS.

Targeting Protein Aggregation in ALS.

Journal: Biomolecules

Published: August 23, 2024

Preparation and Characterization of Zn(II)-Stabilized Aβ42 Oligomers.

Preparation and Characterization of Zn(II)-Stabilized Aβ42 Oligomers.

Journal: ACS chemical neuroscience

Published: July 09, 2024

A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions.

A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions.

Journal: ACS chemical neuroscience

Published: February 28, 2024

Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates.

Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates.

Journal: Molecular pharmaceutics

Published: November 14, 2022

The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity.

The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity.

Journal: Molecules (Basel, Switzerland)

Published: January 18, 2022

Surface-Catalyzed Secondary Nucleation Dominates the Generation of Toxic IAPP Aggregates.

Surface-Catalyzed Secondary Nucleation Dominates the Generation of Toxic IAPP Aggregates.

Journal: Frontiers in molecular biosciences

Published: August 12, 2021

Publisher Correction: Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response.

Publisher Correction: Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response.

Journal: Communications biology

Published: July 27, 2021

Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers.

Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers.

Journal: Frontiers in neuroscience

Published: March 12, 2021

Exogenous misfolded protein oligomers can cross the intestinal barrier and cause a disease phenotype in C. elegans.

Exogenous misfolded protein oligomers can cross the intestinal barrier and cause a disease phenotype in C. elegans.

Journal: Scientific reports

Published: February 14, 2021

Aβ Oligomers Dysregulate Calcium Homeostasis by Mechanosensitive Activation of AMPA and NMDA Receptors.

Aβ Oligomers Dysregulate Calcium Homeostasis by Mechanosensitive Activation of AMPA and NMDA Receptors.

Journal: ACS chemical neuroscience

Published: February 04, 2021

Showing 1-12 of 40

Last Updated: 09/26/2026