Bernard Leroy

Paris, France

Last Updated: 09/26/2026

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Found 13 publications

Low-penetrance TP53 variants are mainly hypomorphic: an underestimated issue with high clinical significance.

Low-penetrance TP53 variants are mainly hypomorphic: an underestimated issue with high clinical significance.

Journal: NPJ genomic medicine
Published: September 20, 2025

The Broad Spectrum of TP53 Mutations in CLL: Evidence of Multiclonality and Novel Mutation Hotspots.

The Broad Spectrum of TP53 Mutations in CLL: Evidence of Multiclonality and Novel Mutation Hotspots.

Journal: Human mutation
Published: December 20, 2022

TP53_PROF: a machine learning model to predict impact of missense mutations in TP53.

TP53_PROF: a machine learning model to predict impact of missense mutations in TP53.

Journal: Briefings in bioinformatics
Published: September 06, 2021

Comprehensive assessment of TP53 loss of function using multiple combinatorial mutagenesis libraries.

Comprehensive assessment of TP53 loss of function using multiple combinatorial mutagenesis libraries.

Journal: Scientific reports
Published: April 15, 2020

Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene.

Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene.

Journal: Cell death and differentiation
Published: March 24, 2020

High prevalence of cancer-associated TP53 variants in the gnomAD database: A word of caution concerning the use of variant filtering.

High prevalence of cancer-associated TP53 variants in the gnomAD database: A word of caution concerning the use of variant filtering.

Journal: Human mutation
Published: October 17, 2018

Seshat: A Web service for accurate annotation, validation, and analysis of TP53 variants generated by conventional and next-generation sequencing.

Seshat: A Web service for accurate annotation, validation, and analysis of TP53 variants generated by conventional and next-generation sequencing.

Journal: Human mutation
Published: January 12, 2018

Recommended Guidelines for Validation, Quality Control, and Reporting of TP53 Variants in Clinical Practice.

Recommended Guidelines for Validation, Quality Control, and Reporting of TP53 Variants in Clinical Practice.

Journal: Cancer research
Published: August 08, 2016

Analysis of TP53 mutation status in human cancer cell lines: a reassessment.

Analysis of TP53 mutation status in human cancer cell lines: a reassessment.

Journal: Human mutation
Published: February 26, 2014

TP53 mutations in human cancer: database reassessment and prospects for the next decade.

TP53 mutations in human cancer: database reassessment and prospects for the next decade.

Journal: Human mutation
Published: January 16, 2014

Recommendations for analyzing and reporting TP53 gene variants in the high-throughput sequencing era.

Recommendations for analyzing and reporting TP53 gene variants in the high-throughput sequencing era.

Journal: Human mutation
Published: December 10, 2013

The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis.

The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis.

Journal: Nucleic acids research
Published: November 20, 2012
Showing 1-12 of 13

Last Updated: 09/26/2026