Birgitta Leuthner

Frankfurter Str. 250
Darmstadt, HE 64293, Germany

Last Updated: 09/26/2026

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Found 23 publications

Discovery of ART5537: A Potent and Selective Small-Molecule Probe for EXO1.

Discovery of ART5537: A Potent and Selective Small-Molecule Probe for EXO1.

Journal: Journal of medicinal chemistry

Published: December 08, 2025

Fragment-Based Discovery and Structure-Led Optimization of MSC778, the First Potent, Selective, and Orally Bioavailable FEN1 Inhibitor.

Fragment-Based Discovery and Structure-Led Optimization of MSC778, the First Potent, Selective, and Orally Bioavailable FEN1 Inhibitor.

Journal: Journal of medicinal chemistry

Published: September 17, 2025

Mechanistic insights into the monotherapy and combination potential of FEN1 inhibition in cancer therapy.

Mechanistic insights into the monotherapy and combination potential of FEN1 inhibition in cancer therapy.

Journal: Nucleic acids research

Published: June 27, 2025

Discovery of potent allosteric antibodies inhibiting EGFR.

Discovery of potent allosteric antibodies inhibiting EGFR.

Journal: mAbs

Published: September 21, 2024

M4205 (IDRX-42) Is a Highly Selective and Potent Inhibitor of Relevant Oncogenic Driver and Resistance Variants of KIT in Cancer.

M4205 (IDRX-42) Is a Highly Selective and Potent Inhibitor of Relevant Oncogenic Driver and Resistance Variants of KIT in Cancer.

Journal: Molecular cancer therapeutics

Published: August 15, 2024

An engineered cereblon optimized for high-throughput screening and molecular glue discovery.

An engineered cereblon optimized for high-throughput screening and molecular glue discovery.

Journal: Cell chemical biology

Published: May 15, 2024

Cryo-EM Structures of CRAF2/14-3-32 and CRAF2/14-3-32/MEK12 Complexes.

Cryo-EM Structures of CRAF2/14-3-32 and CRAF2/14-3-32/MEK12 Complexes.

Journal: Journal of molecular biology

Published: September 15, 2023

Discovery of Cycloalkyl[c]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2α Inhibitors.

Discovery of Cycloalkyl[c]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2α Inhibitors.

Journal: Journal of medicinal chemistry

Published: July 05, 2023

Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models.

Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models.

Journal: Molecular cancer therapeutics

Published: February 15, 2023

Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.

Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.

Journal: ChemMedChem

Published: November 14, 2022

Differences in Sustained Cellular Effects of MET inhibitors Are Driven by Prolonged Target Engagement and Lysosomal Retention.

Differences in Sustained Cellular Effects of MET inhibitors Are Driven by Prolonged Target Engagement and Lysosomal Retention.

Journal: Molecular pharmacology

Published: July 13, 2022

Corrigendum to "Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors" [Bioorg. Med. Chem. Lett. 30 (2020) 127551].

Corrigendum to "Biochemical, cellular and structural characterization of novel and selective ERK3 inhibitors" [Bioorg. Med. Chem. Lett. 30 (2020) 127551].

Journal: Bioorganic & medicinal chemistry letters

Published: August 05, 2021

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Last Updated: 09/26/2026