Bixue Xu

State Key Laboratory Of Discovery And Utilization Of Functional Components In Traditional Chinese Medicine
Guiyang, 550000, China

Last Updated: 09/26/2026

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Found 33 publications

Enantioselective Construction of Spirocyclohexadienones Via NHC-Catalyzed Formal [5 + 1] Annulation Reaction of Dienals.

Enantioselective Construction of Spirocyclohexadienones Via NHC-Catalyzed Formal [5 + 1] Annulation Reaction of Dienals.

Journal: Organic letters

Published: July 27, 2026

BLM as a potential therapeutic target in cutaneous malignant melanoma.

BLM as a potential therapeutic target in cutaneous malignant melanoma.

Journal: Biochemical pharmacology

Published: March 18, 2026

Structure-optimized 4-trifluoromethylquinoline derivatives: Dual enhancement of SGK1 inhibition and anti-prostate cancer efficacy.

Structure-optimized 4-trifluoromethylquinoline derivatives: Dual enhancement of SGK1 inhibition and anti-prostate cancer efficacy.

Journal: Bioorganic chemistry

Published: February 26, 2026

A trifluoromethyl quinazoline inhibits hepatocellular carcinoma proliferation through HDAC1 binding and multi-target mechanisms.

A trifluoromethyl quinazoline inhibits hepatocellular carcinoma proliferation through HDAC1 binding and multi-target mechanisms.

Journal: iScience

Published: February 25, 2026

Design, synthesis, and anti-prostate cancer activity evaluation of novel thieno[2,3-b]pyridine derivatives as potential BLM helicase inhibitors.

Design, synthesis, and anti-prostate cancer activity evaluation of novel thieno[2,3-b]pyridine derivatives as potential BLM helicase inhibitors.

Journal: Molecular diversity

Published: February 14, 2026

Hijacking the Hydrogen Sulfide Axis: A Novel 4-Trifluoromethylquinoline Derivative Suppresses Glioblastoma via Cystathionine γ-Lyase Suppression.

Hijacking the Hydrogen Sulfide Axis: A Novel 4-Trifluoromethylquinoline Derivative Suppresses Glioblastoma via Cystathionine γ-Lyase Suppression.

Journal: Journal of medicinal chemistry

Published: February 03, 2026

A Trifluoromethyl Quinazoline Compound Regulates the Epithelial-Mesenchymal Transition of Prostatic Hyperplasia Cells by Inhibiting the Secretion of TGF-β1 in Stromal Cells.

A Trifluoromethyl Quinazoline Compound Regulates the Epithelial-Mesenchymal Transition of Prostatic Hyperplasia Cells by Inhibiting the Secretion of TGF-β1 in Stromal Cells.

Journal: Current issues in molecular biology

Published: November 20, 2025

A trifluoromethyl quinoline derivative targets SGK1 and modulates the PI3K/AKT pathway to inhibit prostate cancer progression.

A trifluoromethyl quinoline derivative targets SGK1 and modulates the PI3K/AKT pathway to inhibit prostate cancer progression.

Journal: Medical oncology (Northwood, London, England)

Published: September 28, 2025

The fluoroquinoline compound exerts anti-erythroleukemic effects by dual-targeting GLUT1 and the PI3K/AKT signaling pathway.

The fluoroquinoline compound exerts anti-erythroleukemic effects by dual-targeting GLUT1 and the PI3K/AKT signaling pathway.

Journal: Scientific reports

Published: September 25, 2025

Novel trifluoromethylquinoline derivatives as potent tubulin polymerization inhibitors with antitumor activity.

Novel trifluoromethylquinoline derivatives as potent tubulin polymerization inhibitors with antitumor activity.

Journal: Bioorganic & medicinal chemistry

Published: August 07, 2025

Correction: Discovery of novel 4-trifluoromethyl-2-anilinoquinoline derivatives as potential anti-cancer agents targeting SGK1.

Correction: Discovery of novel 4-trifluoromethyl-2-anilinoquinoline derivatives as potential anti-cancer agents targeting SGK1.

Journal: Molecular diversity

Published: April 29, 2025

Quinazoline Derivative kzl052 Suppresses Prostate Cancer by Targeting WRN Helicase to Stabilize DNA Replication Forks.

Quinazoline Derivative kzl052 Suppresses Prostate Cancer by Targeting WRN Helicase to Stabilize DNA Replication Forks.

Journal: International journal of molecular sciences

Published: April 23, 2025

Showing 1-12 of 33

Last Updated: 09/26/2026