Bizhu Chu

Shenzhen, China

Last Updated: 09/26/2026

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Found 25 publications

A Molecular Trimming Strategy for Hypoxia-Tolerant Photosensitizers With Enhanced cGAS-STING Activation.

A Molecular Trimming Strategy for Hypoxia-Tolerant Photosensitizers With Enhanced cGAS-STING Activation.

Journal: Angewandte Chemie (International ed. in English)

Published: March 24, 2026

Design, Synthesis, and Biological Evaluation of Quinoline-Based Hydroxamic Acid Derivatives as Dual DNMT and HDAC Inhibitors with Potent Anti-Breast Cancer Activity.

Design, Synthesis, and Biological Evaluation of Quinoline-Based Hydroxamic Acid Derivatives as Dual DNMT and HDAC Inhibitors with Potent Anti-Breast Cancer Activity.

Journal: Journal of medicinal chemistry

Published: August 29, 2025

A fluorenone-based conjugated polymer nanoparticle applied in drug delivery with real-time detection (color change) via the AILE mechanism.

A fluorenone-based conjugated polymer nanoparticle applied in drug delivery with real-time detection (color change) via the AILE mechanism.

Journal: Nanoscale

Published: May 23, 2025

Targeting HDAC and PARP Enhances STING-Dependent Antitumor Immunity in STING-Deficient Tumor.

Targeting HDAC and PARP Enhances STING-Dependent Antitumor Immunity in STING-Deficient Tumor.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Published: May 01, 2025

DNMT inhibition epigenetically restores the cGAS-STING pathway and activates RIG-I/MDA5-MAVS to enhance antitumor immunity.

DNMT inhibition epigenetically restores the cGAS-STING pathway and activates RIG-I/MDA5-MAVS to enhance antitumor immunity.

Journal: Acta pharmacologica Sinica

Published: April 01, 2025

Applying Spatiotemporal Modeling of Cell Dynamics to Accelerate Drug Development.

Applying Spatiotemporal Modeling of Cell Dynamics to Accelerate Drug Development.

Journal: ACS nano

Published: October 18, 2024

Dual inhibitors of DNMT and HDAC remodels the immune microenvironment of colorectal cancer and enhances the efficacy of anti-PD-L1 therapy.

Dual inhibitors of DNMT and HDAC remodels the immune microenvironment of colorectal cancer and enhances the efficacy of anti-PD-L1 therapy.

Journal: Pharmacological research

Published: April 25, 2024

Bifunctional HDAC and DNMT inhibitor induces viral mimicry activates the innate immune response in triple-negative breast cancer.

Bifunctional HDAC and DNMT inhibitor induces viral mimicry activates the innate immune response in triple-negative breast cancer.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Published: January 22, 2024

Dual inhibitors of DNMT and HDAC induce viral mimicry to induce antitumour immunity in breast cancer.

Dual inhibitors of DNMT and HDAC induce viral mimicry to induce antitumour immunity in breast cancer.

Journal: Cell death discovery

Published: January 12, 2024

Clinical functional proteomics of intercellular signalling in pancreatic cancer.

Clinical functional proteomics of intercellular signalling in pancreatic cancer.

Journal: Nature

Published: July 21, 2023

Novel dual inhibitors of PARP and HDAC induce intratumoral STING-mediated antitumor immunity in triple-negative breast cancer.

Novel dual inhibitors of PARP and HDAC induce intratumoral STING-mediated antitumor immunity in triple-negative breast cancer.

Journal: Cell death & disease

Published: July 08, 2023

Design, synthesis and biological evaluation of pyrimidine base hydroxamic acid derivatives as dual JMJD3 and HDAC inhibitors.

Design, synthesis and biological evaluation of pyrimidine base hydroxamic acid derivatives as dual JMJD3 and HDAC inhibitors.

Journal: Bioorganic & medicinal chemistry letters

Published: July 04, 2023

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Last Updated: 09/26/2026