Brent A. Mclean

Toronto, ON, Canada

Last Updated: 09/26/2026

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Found 27 publications

Loss of PI3Kα Mediates Protection From Myocardial Ischemia-Reperfusion Injury Linked to Preserved Mitochondrial Function.

Loss of PI3Kα Mediates Protection From Myocardial Ischemia-Reperfusion Injury Linked to Preserved Mitochondrial Function.

Journal: Journal of the American Heart Association

Published: June 15, 2023

Central glucagon-like peptide 1 receptor activation inhibits Toll-like receptor agonist-induced inflammation.

Central glucagon-like peptide 1 receptor activation inhibits Toll-like receptor agonist-induced inflammation.

Journal: Cell metabolism

Published: March 20, 2023

Glucagon-like Peptide-1 receptor Tie2+ cells are essential for the cardioprotective actions of liraglutide in mice with experimental myocardial infarction.

Glucagon-like Peptide-1 receptor Tie2+ cells are essential for the cardioprotective actions of liraglutide in mice with experimental myocardial infarction.

Journal: Molecular metabolism

Published: October 17, 2022

Genetic disruption of the Gipr in Apoe-/- mice promotes atherosclerosis.

Genetic disruption of the Gipr in Apoe-/- mice promotes atherosclerosis.

Journal: Molecular metabolism

Published: June 25, 2022

Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced inflammation.

Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced inflammation.

Journal: Cell metabolism

Published: December 06, 2021

Differential importance of endothelial and hematopoietic cell GLP-1Rs for cardiometabolic versus hepatic actions of semaglutide.

Differential importance of endothelial and hematopoietic cell GLP-1Rs for cardiometabolic versus hepatic actions of semaglutide.

Journal: JCI insight

Published: August 05, 2021

Revisiting the Complexity of GLP-1 Action from Sites of Synthesis to Receptor Activation.

Revisiting the Complexity of GLP-1 Action from Sites of Synthesis to Receptor Activation.

Journal: Endocrine reviews

Published: October 09, 2020

Glucagon-Like Peptide-1 Receptor Agonists in Adult Patients With Type 2 Diabetes: Review of Cardiovascular Outcome Trials.

Glucagon-Like Peptide-1 Receptor Agonists in Adult Patients With Type 2 Diabetes: Review of Cardiovascular Outcome Trials.

Journal: Canadian journal of diabetes

Published: July 12, 2019

PI3Kα Pathway Inhibition With Doxorubicin Treatment Results in Distinct Biventricular Atrophy and Remodeling With Right Ventricular Dysfunction.

PI3Kα Pathway Inhibition With Doxorubicin Treatment Results in Distinct Biventricular Atrophy and Remodeling With Right Ventricular Dysfunction.

Journal: Journal of the American Heart Association

Published: May 02, 2019

Inhibition of PI3Kinase-α is pro-arrhythmic and associated with enhanced late Na+ current, contractility, and Ca2+ release in murine hearts.

Inhibition of PI3Kinase-α is pro-arrhythmic and associated with enhanced late Na+ current, contractility, and Ca2+ release in murine hearts.

Journal: Journal of molecular and cellular cardiology

Published: February 21, 2019

Breast Cancer Patients Receiving Anthracycline Chemotherapy and Trastuzumab Have Biventricular Dysfunction and Reduced Heart Mass.

Breast Cancer Patients Receiving Anthracycline Chemotherapy and Trastuzumab Have Biventricular Dysfunction and Reduced Heart Mass.

Journal: Journal of the American College of Cardiology

Published: April 05, 2018

PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease.

PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease.

Journal: Nature communications

Published: November 22, 2017

Showing 1-12 of 27

Last Updated: 09/26/2026