Brian Lacruz-Medel
Barcelona, CT, Spain
Last Updated: 09/26/2026
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Found 14 publications
Assessing the ligand native-like pose using a quantum mechanical-derived hydropathic score for protein-ligand complementarity.
Journal: npj drug discovery
Published: October 26, 2025
Loss-of-function Gαs rare disease variants exert mutation-specific effects on GPCR signaling.
Journal: Science signaling
Published: May 20, 2025
Synthon-Based Strategies Exploiting Molecular Similarity and Protein-Ligand Interactions for Efficient Screening of Ultra-Large Chemical Libraries.
Journal: Journal of chemical information and modeling
Published: April 28, 2025
Small molecule BLVRB redox inhibitor promotes megakaryocytopoiesis and stress thrombopoiesis in vivo.
Journal: Nature communications
Published: July 16, 2024
Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways.
Journal: Nature communications
Published: May 15, 2024
Discovery and characterization of small-molecule TGR5 ligands with agonistic activity.
Journal: European journal of medicinal chemistry
Published: May 09, 2024
Correction: Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling.
Journal: Molecular psychiatry
Published: August 07, 2023
Ligand entry pathways control the chemical space recognized by GPR183.
Journal: Chemical science
Published: October 27, 2022
In Silico Study of Allosteric Communication Networks in GPCR Signaling Bias.
Journal: International journal of molecular sciences
Published: June 22, 2022
Plasma membrane preassociation drives β-arrestin coupling to receptors and activation.
Journal: Cell
Published: March 25, 2022
Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling.
Journal: Molecular psychiatry
Published: February 08, 2022
Publisher Correction: GPCRmd uncovers the dynamics of the 3D-GPCRome.
Journal: Nature methods
Published: July 25, 2020
Last Updated: 09/26/2026