Brian P. Smith

Intensive Care Medicine

1290 Hospital Dr
Saint Johnsbury, VT 05819

Last Updated: 09/26/2026

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Found 72 publications

Discovery of BBO-11818, a Potent and Selective Noncovalent Inhibitor of (ON) and (OFF) KRAS with Activity against Multiple Oncogenic Mutants.

Discovery of BBO-11818, a Potent and Selective Noncovalent Inhibitor of (ON) and (OFF) KRAS with Activity against Multiple Oncogenic Mutants.

Journal: Cancer discovery

Published: July 22, 2025

BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction.

BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction.

Journal: Science (New York, N.Y.)

Published: June 12, 2025

Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine.

Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: May 09, 2025

Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C.

Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C.

Journal: Cancer discovery

Published: June 12, 2024

High-Throughput Cell-Based Screening of Small Molecule KRAS Signaling Inhibitors Using a Homogeneous Time-Resolved Fluorescence (HTRF) Assay.

High-Throughput Cell-Based Screening of Small Molecule KRAS Signaling Inhibitors Using a Homogeneous Time-Resolved Fluorescence (HTRF) Assay.

Journal: Methods in molecular biology (Clifton, N.J.)

Published: April 03, 2024

FLAG-KRAS4B as a Model System for KRAS4B Proteoform and PTM Evaluation by Mass Spectrometry.

FLAG-KRAS4B as a Model System for KRAS4B Proteoform and PTM Evaluation by Mass Spectrometry.

Journal: Methods in molecular biology (Clifton, N.J.)

Published: April 03, 2024

Corrigendum to "Use of an aggregate exposure model to estimate consumer exposure to fragrance ingredients in personal care and cosmetic products" [Regul. Toxicol. Pharmacol. 72 3 (2015) 673-68].

Corrigendum to "Use of an aggregate exposure model to estimate consumer exposure to fragrance ingredients in personal care and cosmetic products" [Regul. Toxicol. Pharmacol. 72 3 (2015) 673-68].

Journal: Regulatory toxicology and pharmacology : RTP

Published: January 04, 2024

American Association for the Surgery of Trauma/American College of Surgeons Committee on Trauma: Clinical protocol for damage-control resuscitation for the adult trauma patient.

American Association for the Surgery of Trauma/American College of Surgeons Committee on Trauma: Clinical protocol for damage-control resuscitation for the adult trauma patient.

Journal: The journal of trauma and acute care surgery

Published: September 12, 2023

Shattered Kidney After Renal Trauma: Should It Be Classified As an American Association for the Surgery of Trauma Grade V Injury?

Shattered Kidney After Renal Trauma: Should It Be Classified As an American Association for the Surgery of Trauma Grade V Injury?

Journal: Urology

Published: April 15, 2023

Grade V renal trauma management: results from the multi-institutional genito-urinary trauma study.

Grade V renal trauma management: results from the multi-institutional genito-urinary trauma study.

Journal: World journal of urology

Published: February 05, 2023

Management of a common hepatic artery pseudoaneurysm after blunt trauma.

Management of a common hepatic artery pseudoaneurysm after blunt trauma.

Journal: Trauma surgery & acute care open

Published: May 06, 2022

Professionalism of Admitting and Consulting Services and Trauma Patient Outcomes.

Professionalism of Admitting and Consulting Services and Trauma Patient Outcomes.

Journal: Annals of surgery

Published: February 21, 2022

Showing 1-12 of 72

Last Updated: 09/26/2026