Brian S. Mantilla

Av. Lineu Prestes 1374, Sala 24, Cidade Universitária
Sao Paulo, SP, Brazil

Last Updated: 09/26/2026

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Found 15 publications

Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in Trypanosoma cruzi.

Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in Trypanosoma cruzi.

Journal: mBio
Published: April 02, 2025

Discovery of Trypanosoma brucei inhibitors enabled by a unified synthesis of diverse sulfonyl fluorides.

Discovery of Trypanosoma brucei inhibitors enabled by a unified synthesis of diverse sulfonyl fluorides.

Journal: Communications chemistry
Published: August 22, 2024

Evaluation of the Leishmania Inositol Phosphorylceramide Synthase as a Drug Target Using a Chemical and Genetic Approach.

Evaluation of the Leishmania Inositol Phosphorylceramide Synthase as a Drug Target Using a Chemical and Genetic Approach.

Journal: ACS infectious diseases
Published: July 18, 2024

An X-Domain Phosphoinositide Phospholipase C (PI-PLC-like) of Trypanosoma brucei Has a Surface Localization and Is Essential for Proliferation.

An X-Domain Phosphoinositide Phospholipase C (PI-PLC-like) of Trypanosoma brucei Has a Surface Localization and Is Essential for Proliferation.

Journal: Pathogens (Basel, Switzerland)
Published: January 30, 2023

Transcriptome-Wide Identification of Coding and Noncoding RNA-Binding Proteins Defines the Comprehensive RNA Interactome of Leishmania mexicana.

Transcriptome-Wide Identification of Coding and Noncoding RNA-Binding Proteins Defines the Comprehensive RNA Interactome of Leishmania mexicana.

Journal: Microbiology spectrum
Published: February 09, 2022

The Histidine Ammonia Lyase of Trypanosoma cruzi Is Involved in Acidocalcisome Alkalinization and Is Essential for Survival under Starvation Conditions.

The Histidine Ammonia Lyase of Trypanosoma cruzi Is Involved in Acidocalcisome Alkalinization and Is Essential for Survival under Starvation Conditions.

Journal: mBio
Published: November 02, 2021

Higher expression of proline dehydrogenase altered mitochondrial function and increased Trypanosoma cruzi differentiation in vitro and in the insect vector.

Higher expression of proline dehydrogenase altered mitochondrial function and increased Trypanosoma cruzi differentiation in vitro and in the insect vector.

Journal: The Biochemical journal
Published: June 23, 2021

The Inositol Pyrophosphate Biosynthetic Pathway of Trypanosoma cruzi.

The Inositol Pyrophosphate Biosynthetic Pathway of Trypanosoma cruzi.

Journal: ACS chemical biology
Published: January 07, 2021

Affinity-based proteomics reveals novel targets of inositol pyrophosphate (5-IP7 )-dependent phosphorylation and binding in Trypanosoma cruzi replicative stages.

Affinity-based proteomics reveals novel targets of inositol pyrophosphate (5-IP7 )-dependent phosphorylation and binding in Trypanosoma cruzi replicative stages.

Journal: Molecular microbiology
Published: October 19, 2020

Trypanosoma cruzi synthesizes proline via a Δ1-pyrroline-5-carboxylate reductase whose activity is fine-tuned by NADPH cytosolic pools.

Trypanosoma cruzi synthesizes proline via a Δ1-pyrroline-5-carboxylate reductase whose activity is fine-tuned by NADPH cytosolic pools.

Journal: The Biochemical journal
Published: March 23, 2020

Metabolomic profiling reveals a finely tuned, starvation-induced metabolic switch in Trypanosoma cruzi epimastigotes.

Metabolomic profiling reveals a finely tuned, starvation-induced metabolic switch in Trypanosoma cruzi epimastigotes.

Journal: The Journal of biological chemistry
Published: January 25, 2017

Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector.

Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector.

Journal: PLoS pathogens
Published: July 25, 2016
Showing 1-12 of 15

Last Updated: 09/26/2026