Cai-guang G. Yang

State Key Laboratory Of Drug Research
Shanghai, China

Last Updated: 09/26/2026

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Found 87 publications

Structure-Based Design of a Highly Potent Dual-Competitive FTO Inhibitor for Targeted m6A Demethylase Inhibition in AML.

Structure-Based Design of a Highly Potent Dual-Competitive FTO Inhibitor for Targeted m6A Demethylase Inhibition in AML.

Journal: Journal of medicinal chemistry

Published: November 05, 2025

Mitochondrial ClpX Inhibition Induces Ferroptosis and Blocks Pancreatic Cancer Cell Proliferation.

Mitochondrial ClpX Inhibition Induces Ferroptosis and Blocks Pancreatic Cancer Cell Proliferation.

Journal: Chembiochem : a European journal of chemical biology

Published: July 21, 2025

Development of Orally Bioavailable FTO Inhibitors with Potent Antileukemia Efficacy.

Development of Orally Bioavailable FTO Inhibitors with Potent Antileukemia Efficacy.

Journal: Journal of medicinal chemistry

Published: June 28, 2025

Modular Synthesis of the Potent Antibiotic Amycolamicin and Diastereomeric Analogues Thereof.

Modular Synthesis of the Potent Antibiotic Amycolamicin and Diastereomeric Analogues Thereof.

Journal: Organic letters

Published: April 02, 2025

A patenting perspective of fat mass and obesity associated protein (FTO) inhibitors: 2017-present.

A patenting perspective of fat mass and obesity associated protein (FTO) inhibitors: 2017-present.

Journal: Expert opinion on therapeutic patents

Published: March 07, 2025

Identification of RAPGEF3 as the therapeutic vulnerability of basal-subtype lung squamous cell carcinoma.

Identification of RAPGEF3 as the therapeutic vulnerability of basal-subtype lung squamous cell carcinoma.

Journal: Oncogene

Published: February 19, 2025

Structure-Based Development of a Covalent Inhibitor Targeting Streptococcus Pyogenes over Staphylococcus Aureus Sortase A.

Structure-Based Development of a Covalent Inhibitor Targeting Streptococcus Pyogenes over Staphylococcus Aureus Sortase A.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany)

Published: February 11, 2025

Discovery of Novel RNA Demethylase FTO Inhibitors Featuring an Acylhydrazone Scaffold with Potent Antileukemia Activity.

Discovery of Novel RNA Demethylase FTO Inhibitors Featuring an Acylhydrazone Scaffold with Potent Antileukemia Activity.

Journal: Journal of medicinal chemistry

Published: January 17, 2025

Development of 3-arylaminothiophenic-2-carboxylic acid derivatives as new FTO inhibitors showing potent antileukemia activities.

Development of 3-arylaminothiophenic-2-carboxylic acid derivatives as new FTO inhibitors showing potent antileukemia activities.

Journal: European journal of medicinal chemistry

Published: January 16, 2025

Applying natural product repurposing strategy to identify baicalein as novel caseinolytic protease P inhibitor and its application in the treatment of rice bacterial diseases.

Applying natural product repurposing strategy to identify baicalein as novel caseinolytic protease P inhibitor and its application in the treatment of rice bacterial diseases.

Journal: Pesticide biochemistry and physiology

Published: January 08, 2025

Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Staphylococcus aureus Infection.

Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Staphylococcus aureus Infection.

Journal: Journal of medicinal chemistry

Published: January 06, 2025

Discovery of novel seven-membered ring derivatives of ONC212 as caseinolytic protease P protein activators using the ring expansion strategy: Rational design, synthesis, and antibacterial evaluation.

Discovery of novel seven-membered ring derivatives of ONC212 as caseinolytic protease P protein activators using the ring expansion strategy: Rational design, synthesis, and antibacterial evaluation.

Journal: International journal of biological macromolecules

Published: December 26, 2024

Showing 1-12 of 87

Last Updated: 09/26/2026