Carl A. Whatling
BioPharmaceuticals R&D, AstraZeneca
Goeteborg, O, Sweden
Goeteborg, O, Sweden
Last Updated: 09/26/2026
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Found 26 publications
A Phase 2a Trial of Myeloperoxidase Inhibitor Mitiperstat in Non-Cirrhotic Metabolic Dysfunction-Associated Steatohepatitis.
Journal: Liver international : official journal of the International Association for the Study of the Liver
Published: July 02, 2025
Safety, Tolerability, and Pharmacodynamics of AZD3366 (Optimized Human CD39L3 Apyrase) Alone and in Combination With Ticagrelor and Acetylsalicylic Acid: A Phase 1, Randomized, Placebo-Controlled Study.
Journal: Journal of the American Heart Association
Published: May 28, 2024
Rationale and design of ENDEAVOR: A sequential phase 2b-3 randomized clinical trial to evaluate the effect of myeloperoxidase inhibition on symptoms and exercise capacity in heart failure with preserved or mildly reduced ejection fraction.
Journal: European journal of heart failure
Published: March 01, 2023
A mechanistic framework for cardiometabolic and coronary artery diseases.
Journal: Nature cardiovascular research
Published: October 24, 2022
Recombinant Apyrase (AZD3366) Against Myocardial Reperfusion Injury.
Journal: Cardiovascular drugs and therapy
Published: February 17, 2022
Pharmacokinetics, Pharmacodynamics, and Tolerability of AZD5718, an Oral 5-Lipoxygenase-Activating Protein (FLAP) Inhibitor, in Healthy Japanese Male Subjects.
Journal: Clinical drug investigation
Published: August 31, 2021
Association of genetic variations with NAFLD in lean individuals.
Journal: Liver international : official journal of the International Association for the Study of the Liver
Published: June 07, 2021
Design of FLAIR: a Phase 2b Study of the 5-Lipoxygenase Activating Protein Inhibitor AZD5718 in Patients With Proteinuric CKD.
Journal: Kidney international reports
Published: April 12, 2021
Novel Lesional Transcriptional Signature Separates Atherosclerosis With and Without Diabetes in Yorkshire Swine and Humans.
Journal: Arteriosclerosis, thrombosis, and vascular biology
Published: February 11, 2021
Diastolic dysfunction and impaired cardiac output reserve in dysmetabolic nonhuman primate with proteinuria.
Journal: Journal of diabetes and its complications
Published: December 06, 2020
Early Clinical Experience With AZD4831, A Novel Myeloperoxidase Inhibitor, Developed for Patients With Heart Failure With Preserved Ejection Fraction.
Journal: Clinical and translational science
Published: April 09, 2020
Development of a highly sensitive liquid chromatography-mass spectrometry method to quantify plasma leukotriene E4 and demonstrate pharmacological suppression of endogenous 5-LO pathway activity in man.
Journal: Prostaglandins & other lipid mediators
Published: December 19, 2019
Last Updated: 09/26/2026