Last Updated: 09/26/2026
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Found 15 publications
Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism.
Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association
Published: December 21, 2023
Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates.
Journal: Journal of medicinal chemistry
Published: August 14, 2020
Anti-Lymphocyte Antigen 6 Complex, Locus E-Seco-Cyclopropabenzindol-4-One-Dimer Antibody-Drug Conjugate That Forms Adduct with α1-Microglobulin Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: June 14, 2020
Calicheamicin Antibody-Drug Conjugates with Improved Properties.
Journal: Molecular cancer therapeutics
Published: April 29, 2020
Improved translation of stability for conjugated antibodies using an in vitro whole blood assay.
Journal: mAbs
Published: January 31, 2020
Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα).
Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα).
Journal: Bioorganic & medicinal chemistry letters
Published: October 29, 2019
Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo.
Journal: Bioconjugate chemistry
Published: April 11, 2019
Exploration of Pyrrolobenzodiazepine (PBD)-Dimers Containing Disulfide-Based Prodrugs as Payloads for Antibody-Drug Conjugates.
Journal: Molecular pharmaceutics
Published: July 25, 2018
Modulating Antibody-Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification.
Journal: Bioconjugate chemistry
Published: February 27, 2018
High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers.
Journal: Bioconjugate chemistry
Published: February 10, 2018
Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein- and Peptide-Payload Conjugates: Application to THIOMAB Antibody-Drug Conjugates.
Journal: Bioconjugate chemistry
Published: June 22, 2017
Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody-Drug Conjugates with Self-Immolative Disulfide Linkers.
Journal: Molecular cancer therapeutics
Published: September 29, 2016
Last Updated: 09/26/2026