Carlos M. Fraga

Cidade Universitaria, RJ 21941902, Brazil

Last Updated: 09/26/2026

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Found 78 publications

Drug Discovery for Histone Deacetylase Inhibition: Past, Present and Future of Zinc-Binding Groups.

Drug Discovery for Histone Deacetylase Inhibition: Past, Present and Future of Zinc-Binding Groups.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: March 16, 2025

Benign-by-Design SAHA Analogues for Human and Animal Vector-Borne Parasitic Diseases.

Benign-by-Design SAHA Analogues for Human and Animal Vector-Borne Parasitic Diseases.

Journal: ACS medicinal chemistry letters

Published: May 28, 2024

Selective inhibition of HDAC6 by N-acylhydrazone derivative reduces the proliferation and induces senescence in carcinoma hepatocellular cells.

Selective inhibition of HDAC6 by N-acylhydrazone derivative reduces the proliferation and induces senescence in carcinoma hepatocellular cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA

Published: May 03, 2024

Remapping the Chemical Space and the Pharmacological Space of Drugs: What Can We Expect from the Road Ahead?

Remapping the Chemical Space and the Pharmacological Space of Drugs: What Can We Expect from the Road Ahead?

Journal: Pharmaceuticals (Basel, Switzerland)

Published: March 31, 2024

Molecular hybridization: a powerful tool for multitarget drug discovery.

Molecular hybridization: a powerful tool for multitarget drug discovery.

Journal: Expert opinion on drug discovery

Published: March 08, 2024

Cytotoxic and Antiproliferative Activity of LASSBio-2208 and the Attempts to Determine Its Drug Metabolism and Pharmacokinetics In Vitro Profile.

Cytotoxic and Antiproliferative Activity of LASSBio-2208 and the Attempts to Determine Its Drug Metabolism and Pharmacokinetics In Vitro Profile.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: February 13, 2024

The Magic Methyl and Its Tricks in Drug Discovery and Development.

The Magic Methyl and Its Tricks in Drug Discovery and Development.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: July 19, 2023

Imidazole: Synthesis, Functionalization and Physicochemical Properties of a Privileged Structure in Medicinal Chemistry.

Imidazole: Synthesis, Functionalization and Physicochemical Properties of a Privileged Structure in Medicinal Chemistry.

Journal: Molecules (Basel, Switzerland)

Published: December 10, 2022

Novel Regioisomeric Analogues of Naphthyl-N-Acylhydrazone Derivatives and Their Anti-Inflammatory Effects.

Novel Regioisomeric Analogues of Naphthyl-N-Acylhydrazone Derivatives and Their Anti-Inflammatory Effects.

Journal: International journal of molecular sciences

Published: October 13, 2022

2-Arylpropionic Acid Pyrazolamides as Cannabinoid CB2 Receptor Inverse Agonists Endowed with Anti-Inflammatory Properties.

2-Arylpropionic Acid Pyrazolamides as Cannabinoid CB2 Receptor Inverse Agonists Endowed with Anti-Inflammatory Properties.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: October 02, 2022

Design, Synthesis and Pharmacological Evaluation of Novel Conformationally Restricted N-arylpiperazine Derivatives Characterized as D2/D3 Receptor Ligands, Candidates for the Treatment of Neurodegenerative Diseases.

Design, Synthesis and Pharmacological Evaluation of Novel Conformationally Restricted N-arylpiperazine Derivatives Characterized as D2/D3 Receptor Ligands, Candidates for the Treatment of Neurodegenerative Diseases.

Journal: Biomolecules

Published: July 12, 2022

Novel p38 Mitogen-Activated Protein Kinase Inhibitor Reverses Hypoxia-Induced Pulmonary Arterial Hypertension in Rats.

Novel p38 Mitogen-Activated Protein Kinase Inhibitor Reverses Hypoxia-Induced Pulmonary Arterial Hypertension in Rats.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: June 07, 2022

Showing 1-12 of 78

Last Updated: 09/26/2026