Carmela De Santo

Birmingham, ENG B152TT, United Kingdom

Last Updated: 09/26/2026

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Found 27 publications

The anti-CD33 antibody drug conjugate gemtuzumab ozogamicin depletes and functionally resets CD33+ myeloid-derived suppressor cells in patients with metastatic cancer: a phase 2 single-arm, open-label trial.

The anti-CD33 antibody drug conjugate gemtuzumab ozogamicin depletes and functionally resets CD33+ myeloid-derived suppressor cells in patients with metastatic cancer: a phase 2 single-arm, open-label trial.

Journal: Journal of leukocyte biology

Published: December 12, 2025

PARC: a phase I/II study evaluating the safety and activity of pegylated recombinant human arginase BCT-100 in relapsed/refractory cancers of children and young adults.

PARC: a phase I/II study evaluating the safety and activity of pegylated recombinant human arginase BCT-100 in relapsed/refractory cancers of children and young adults.

Journal: Frontiers in oncology

Published: September 18, 2023

Neratinib could be effective as monotherapy or in combination with trastuzumab in HER2-low breast cancer cells and organoid models.

Neratinib could be effective as monotherapy or in combination with trastuzumab in HER2-low breast cancer cells and organoid models.

Journal: British journal of cancer

Published: June 13, 2023

A randomised evaluation of low-dose Ara-C plus pegylated recombinant arginase BCT-100 versus low dose Ara-C in older unfit patients with acute myeloid leukaemia: Results from the LI-1 trial.

A randomised evaluation of low-dose Ara-C plus pegylated recombinant arginase BCT-100 versus low dose Ara-C in older unfit patients with acute myeloid leukaemia: Results from the LI-1 trial.

Journal: British journal of haematology

Published: August 24, 2022

Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment.

Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment.

Journal: Blood advances

Published: June 06, 2022

Invariant NKT cells metabolically adapt to the acute myeloid leukaemia environment.

Invariant NKT cells metabolically adapt to the acute myeloid leukaemia environment.

Journal: Cancer immunology, immunotherapy : CII

Published: February 18, 2022

G-CSF induces CD15+ CD14+ cells from granulocytes early in the physiological environment of pregnancy and the cancer immunosuppressive microenvironment.

G-CSF induces CD15+ CD14+ cells from granulocytes early in the physiological environment of pregnancy and the cancer immunosuppressive microenvironment.

Journal: Clinical & translational immunology

Published: November 09, 2021

TGF-β orchestrates the phenotype and function of monocytic myeloid-derived suppressor cells in colorectal cancer.

TGF-β orchestrates the phenotype and function of monocytic myeloid-derived suppressor cells in colorectal cancer.

Journal: Cancer immunology, immunotherapy : CII

Published: June 23, 2021

Targeting Amino Acid Metabolic Vulnerabilities in Myeloid Malignancies.

Targeting Amino Acid Metabolic Vulnerabilities in Myeloid Malignancies.

Journal: Frontiers in oncology

Published: March 01, 2021

Characterizing EBV-associated lymphoproliferative diseases and the role of myeloid-derived suppressor cells.

Characterizing EBV-associated lymphoproliferative diseases and the role of myeloid-derived suppressor cells.

Journal: Blood

Published: February 28, 2020

Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity.

Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity.

Journal: Blood

Published: December 27, 2019

MDSC targeting with Gemtuzumab ozogamicin restores T cell immunity and immunotherapy against cancers.

MDSC targeting with Gemtuzumab ozogamicin restores T cell immunity and immunotherapy against cancers.

Journal: EBioMedicine

Published: June 04, 2019

Showing 1-12 of 27

Last Updated: 09/26/2026