Caroline A. Austin

Central Parkway
Newcastle Upon Tyne, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 42 publications

Analysis of gene expression changes upon topobexin treatment and TOP2B-knockout in hiPSC derived cardiomyocytes.

Analysis of gene expression changes upon topobexin treatment and TOP2B-knockout in hiPSC derived cardiomyocytes.

Journal: Biology open

Published: March 28, 2026

Topoisomerase II DNA Cleavage Assay Using Fluorescently Labelled Double-Stranded Oligonucleotides.

Topoisomerase II DNA Cleavage Assay Using Fluorescently Labelled Double-Stranded Oligonucleotides.

Journal: Methods in molecular biology (Clifton, N.J.)

Published: May 15, 2025

Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection.

Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection.

Journal: Nature communications

Published: October 28, 2024

TOP2B is required for compartment strength changes upon retinoic acid treatment in SH-SY5Y cells.

TOP2B is required for compartment strength changes upon retinoic acid treatment in SH-SY5Y cells.

Journal: Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology

Published: September 17, 2024

Exploring the effects of topoisomerase II inhibitor XK469 on anthracycline cardiotoxicity and DNA damage.

Exploring the effects of topoisomerase II inhibitor XK469 on anthracycline cardiotoxicity and DNA damage.

Journal: Toxicological sciences : an official journal of the Society of Toxicology

Published: January 30, 2024

Myeloperoxidase inhibition protects bone marrow mononuclear cells from DNA damage induced by the TOP2 poison anti-cancer drug etoposide.

Myeloperoxidase inhibition protects bone marrow mononuclear cells from DNA damage induced by the TOP2 poison anti-cancer drug etoposide.

Journal: FEBS open bio

Published: January 15, 2024

XPF interacts with TOP2B for R-loop processing and DNA looping on actively transcribed genes.

XPF interacts with TOP2B for R-loop processing and DNA looping on actively transcribed genes.

Journal: Science advances

Published: November 08, 2023

To Break or Not to Break: The Role of TOP2B in Transcription.

To Break or Not to Break: The Role of TOP2B in Transcription.

Journal: International journal of molecular sciences

Published: September 08, 2023

DNA fragility at the KMT2A/MLL locus: insights from old and new technologies.

DNA fragility at the KMT2A/MLL locus: insights from old and new technologies.

Journal: Open biology

Published: January 11, 2023

Two type I topoisomerases maintain DNA topology in human mitochondria.

Two type I topoisomerases maintain DNA topology in human mitochondria.

Journal: Nucleic acids research

Published: June 16, 2022

A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193.

A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193.

Journal: Structure (London, England : 1993)

Published: January 21, 2022

Human topoisomerases and their roles in genome stability and organization.

Human topoisomerases and their roles in genome stability and organization.

Journal: Nature reviews. Molecular cell biology

Published: January 06, 2022

Showing 1-12 of 42

Last Updated: 09/26/2026