Catherine Roch

Allschwil, BL 4123, Switzerland

Last Updated: 09/26/2026

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Found 23 publications

Discovery and In-Vivo Characterization of Kv7 Channel Openers through a Phenotypic Approach.

Discovery and In-Vivo Characterization of Kv7 Channel Openers through a Phenotypic Approach.

Journal: Journal of medicinal chemistry
Published: August 12, 2025

Discovery of a New Class of Orexin 2 Receptor Agonists as a Potential Treatment for Narcolepsy.

Discovery of a New Class of Orexin 2 Receptor Agonists as a Potential Treatment for Narcolepsy.

Journal: Journal of medicinal chemistry
Published: May 05, 2025

IDOR-1104-0086, a novel Kv7 channel activator with antiseizure effects in rodents.

IDOR-1104-0086, a novel Kv7 channel activator with antiseizure effects in rodents.

Journal: Neuropharmacology
Published: April 26, 2025

Antiseizure potential of the triple T-type calcium channel blocker ACT-709478 (apinocaltamide) in rodent models.

Antiseizure potential of the triple T-type calcium channel blocker ACT-709478 (apinocaltamide) in rodent models.

Journal: Epilepsia
Published: November 13, 2024

Pyrazole derivatives as selective orexin-2 receptor antagonists (2-SORA): synthesis, structure-activity-relationship, and sleep-promoting properties in rats.

Pyrazole derivatives as selective orexin-2 receptor antagonists (2-SORA): synthesis, structure-activity-relationship, and sleep-promoting properties in rats.

Journal: RSC medicinal chemistry
Published: October 14, 2023

The orexin story and orexin receptor antagonists for the treatment of insomnia.

The orexin story and orexin receptor antagonists for the treatment of insomnia.

Journal: Journal of sleep research
Published: February 20, 2023

Nonclinical pharmacology of daridorexant: a new dual orexin receptor antagonist for the treatment of insomnia.

Nonclinical pharmacology of daridorexant: a new dual orexin receptor antagonist for the treatment of insomnia.

Journal: Psychopharmacology
Published: May 04, 2021

The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia Disorders.

The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia Disorders.

Journal: ChemMedChem
Published: July 15, 2020

From Oxadiazole to Triazole Analogues: Optimization toward a Dual Orexin Receptor Antagonist with Improved in vivo Efficacy in Dogs.

From Oxadiazole to Triazole Analogues: Optimization toward a Dual Orexin Receptor Antagonist with Improved in vivo Efficacy in Dogs.

Journal: ChemMedChem
Published: November 01, 2019

Oxadiazole Derivatives as Dual Orexin Receptor Antagonists: Synthesis, Structure-Activity Relationships, and Sleep-Promoting Properties in Rats.

Oxadiazole Derivatives as Dual Orexin Receptor Antagonists: Synthesis, Structure-Activity Relationships, and Sleep-Promoting Properties in Rats.

Journal: ChemMedChem
Published: April 17, 2019

Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies.

Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies.

Journal: Journal of medicinal chemistry
Published: November 09, 2017

Milestones to the Discovery of T-type Calcium Channel Blockers for the Treatment of Generalized Epilepsies.

Milestones to the Discovery of T-type Calcium Channel Blockers for the Treatment of Generalized Epilepsies.

Journal: Chimia
Published: October 27, 2017
Showing 1-12 of 23

Last Updated: 09/26/2026