Chantelle F. Sephton

Quebec, QC G1J2G3, Canada

Last Updated: 09/26/2026

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Found 21 publications

GATOR1 signaling defects promote astrocytic metabolic rewiring and excitatory neurotransmitter cycling.

GATOR1 signaling defects promote astrocytic metabolic rewiring and excitatory neurotransmitter cycling.

Journal: EMBO reports

Published: October 01, 2025

Targeting lipid droplets in FUS-linked amyotrophic lateral sclerosis mitigates neuronal and astrocytic lipotoxicity.

Targeting lipid droplets in FUS-linked amyotrophic lateral sclerosis mitigates neuronal and astrocytic lipotoxicity.

Journal: Brain : a journal of neurology

Published: December 23, 2024

Reversal of cognitive deficits in FUSR521G amyotrophic lateral sclerosis mice by arimoclomol and a class I histone deacetylase inhibitor independent of heat shock protein induction.

Reversal of cognitive deficits in FUSR521G amyotrophic lateral sclerosis mice by arimoclomol and a class I histone deacetylase inhibitor independent of heat shock protein induction.

Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Published: April 08, 2024

GATOR1 Mutations Impair PI3 Kinase-Dependent Growth Factor Signaling Regulation of mTORC1.

GATOR1 Mutations Impair PI3 Kinase-Dependent Growth Factor Signaling Regulation of mTORC1.

Journal: International journal of molecular sciences

Published: January 22, 2024

Impact of histone deacetylase inhibition and arimoclomol on heat shock protein expression and disease biomarkers in primary culture models of familial ALS.

Impact of histone deacetylase inhibition and arimoclomol on heat shock protein expression and disease biomarkers in primary culture models of familial ALS.

Journal: Cell stress & chaperones

Published: December 14, 2023

Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation.

Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation.

Journal: The Journal of biological chemistry

Published: September 18, 2023

Neuronal dysfunction caused by FUSR521G promotes ALS-associated phenotypes that are attenuated by NF-κB inhibition.

Neuronal dysfunction caused by FUSR521G promotes ALS-associated phenotypes that are attenuated by NF-κB inhibition.

Journal: Acta neuropathologica communications

Published: August 04, 2023

Synaptic dysfunction in ALS and FTD: anatomical and molecular changes provide insights into mechanisms of disease.

Synaptic dysfunction in ALS and FTD: anatomical and molecular changes provide insights into mechanisms of disease.

Journal: Frontiers in molecular neuroscience

Published: July 21, 2022

Widespread alterations in microRNA biogenesis in human Huntington's disease putamen.

Widespread alterations in microRNA biogenesis in human Huntington's disease putamen.

Journal: Acta neuropathologica communications

Published: May 24, 2022

A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics.

A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics.

Journal: Acta neuropathologica communications

Published: September 27, 2021

NPRL2 Inhibition of mTORC1 Controls Sodium Channel Expression and Brain Amino Acid Homeostasis.

NPRL2 Inhibition of mTORC1 Controls Sodium Channel Expression and Brain Amino Acid Homeostasis.

Journal: eNeuro

Published: July 26, 2021

hnRNP A1B, a Splice Variant of HNRNPA1, Is Spatially and Temporally Regulated.

hnRNP A1B, a Splice Variant of HNRNPA1, Is Spatially and Temporally Regulated.

Journal: Frontiers in neuroscience

Published: June 12, 2021

Showing 1-12 of 21

Last Updated: 09/26/2026