Charles H. Large

Stevenage, ENG, United Kingdom

Last Updated: 09/26/2026

Save publications for later

Sign Up

Not sure about your diagnosis?

Check Your Symptoms

Found 27 publications

AUT00206, a novel and selective Kv3.1/3.2 channel modulator, restores cognitive dysfunction and negative symptoms in an animal model for schizophrenia symptomatology.

AUT00206, a novel and selective Kv3.1/3.2 channel modulator, restores cognitive dysfunction and negative symptoms in an animal model for schizophrenia symptomatology.

Journal: Journal of psychopharmacology (Oxford, England)

Published: August 12, 2026

Kv3 channel agonist ameliorates the phenotype of a mouse model of amyotrophic lateral sclerosis.

Kv3 channel agonist ameliorates the phenotype of a mouse model of amyotrophic lateral sclerosis.

Journal: Acta neuropathologica communications

Published: February 17, 2025

Pharmacological modulation of Kv3 voltage-gated potassium channels regulates fear discrimination and expression in a response-dependent manner.

Pharmacological modulation of Kv3 voltage-gated potassium channels regulates fear discrimination and expression in a response-dependent manner.

Journal: Progress in neuro-psychopharmacology & biological psychiatry

Published: May 12, 2023

The binding and mechanism of a positive allosteric modulator of Kv3 channels.

The binding and mechanism of a positive allosteric modulator of Kv3 channels.

Journal: Nature communications

Published: April 10, 2023

Targeted therapy improves cellular dysfunction, ataxia, and seizure susceptibility in a model of a progressive myoclonus epilepsy.

Targeted therapy improves cellular dysfunction, ataxia, and seizure susceptibility in a model of a progressive myoclonus epilepsy.

Journal: Cell reports. Medicine

Published: February 09, 2023

The effect of AUT00206, a Kv3 potassium channel modulator, on dopamine synthesis capacity and the reliability of [18F]-FDOPA imaging in schizophrenia.

The effect of AUT00206, a Kv3 potassium channel modulator, on dopamine synthesis capacity and the reliability of [18F]-FDOPA imaging in schizophrenia.

Journal: Journal of psychopharmacology (Oxford, England)

Published: September 27, 2022

Kv3 Channels Contribute to the Excitability of Subpopulations of Spinal Cord Neurons in Lamina VII.

Kv3 Channels Contribute to the Excitability of Subpopulations of Spinal Cord Neurons in Lamina VII.

Journal: eNeuro

Published: December 13, 2021

The effects of AUT00206, a novel Kv3.1/3.2 potassium channel modulator, on task-based reward system activation: a test of mechanism in schizophrenia.

The effects of AUT00206, a novel Kv3.1/3.2 potassium channel modulator, on task-based reward system activation: a test of mechanism in schizophrenia.

Journal: Psychopharmacology

Published: November 26, 2021

Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer's disease.

Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer's disease.

Journal: Brain and neuroscience advances

Published: November 24, 2021

Sparsely Distributed, Pre-synaptic Kv3 K+ Channels Control Spontaneous Firing and Cross-Unit Synchrony via the Regulation of Synaptic Noise in an Auditory Brainstem Circuit.

Sparsely Distributed, Pre-synaptic Kv3 K+ Channels Control Spontaneous Firing and Cross-Unit Synchrony via the Regulation of Synaptic Noise in an Auditory Brainstem Circuit.

Journal: Frontiers in cellular neuroscience

Published: June 12, 2021

Effect of Kv3 channel modulators on auditory temporal resolution in aged Fischer 344 rats.

Effect of Kv3 channel modulators on auditory temporal resolution in aged Fischer 344 rats.

Journal: Hearing research

Published: August 17, 2020

Why Is There No Cure for Tinnitus?

Why Is There No Cure for Tinnitus?

Journal: Frontiers in neuroscience

Published: April 15, 2019

Showing 1-12 of 27

Last Updated: 09/26/2026