Cheng-chang Chen
Munich, BY, Germany
Last Updated: 09/26/2026
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Found 19 publications
Expanding the Toolbox: Novel Modulators of Endolysosomal Cation Channels.
Journal: Handbook of experimental pharmacology
Published: July 28, 2022
Two-pore and TRP cation channels in endolysosomal osmo-/mechanosensation and volume regulation.
Journal: Biochimica et biophysica acta. Molecular cell research
Published: October 16, 2020
Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2.
Journal: Scientific reports
Published: October 15, 2020
Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3.
Journal: European journal of medicinal chemistry
Published: August 18, 2020
TRPML2 is an osmo/mechanosensitive cation channel in endolysosomal organelles.
Journal: Science advances
Published: February 28, 2020
Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function.
Journal: eLife
Published: December 23, 2019
TRPML Cation Channels in Inflammation and Immunity.
Journal: Frontiers in immunology
Published: November 28, 2019
Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells.
Journal: eLife
Published: July 01, 2018
TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms.
Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: September 20, 2017
Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes.
Journal: Nature protocols
Published: July 21, 2017
Small Molecules for Early Endosome-Specific Patch Clamping.
Journal: Cell chemical biology
Published: January 25, 2017
Last Updated: 09/26/2026