Christian D. Klein

Heidelberg, BW 69120, Germany

Last Updated: 09/26/2026

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Found 54 publications

Decoding of Inconsistent Biological Data: A Critical Step toward Enhanced AI Predictivity in Drug Discovery.

Decoding of Inconsistent Biological Data: A Critical Step toward Enhanced AI Predictivity in Drug Discovery.

Journal: ACS pharmacology & translational science

Published: October 10, 2025

Discovery of Pyrazole-3-Carboxylic Acid Derivatives as Dengue Virus Protease Inhibitors with Antiviral Activity.

Discovery of Pyrazole-3-Carboxylic Acid Derivatives as Dengue Virus Protease Inhibitors with Antiviral Activity.

Journal: ACS medicinal chemistry letters

Published: April 15, 2025

Efficient Acyloxymethylation of Psilocin and Other Tryptamines Yielding ACOM Prodrugs for Psychedelic-Assisted Therapy.

Efficient Acyloxymethylation of Psilocin and Other Tryptamines Yielding ACOM Prodrugs for Psychedelic-Assisted Therapy.

Journal: Archiv der Pharmazie

Published: April 01, 2025

Antiviral drug discovery with an optimized biochemical dengue protease assay: Improved predictive power for antiviral efficacy.

Antiviral drug discovery with an optimized biochemical dengue protease assay: Improved predictive power for antiviral efficacy.

Journal: Antiviral research

Published: June 12, 2024

Alternate recognition by dengue protease: Proteolytic and binding assays provide functional evidence beyond an induced-fit.

Alternate recognition by dengue protease: Proteolytic and binding assays provide functional evidence beyond an induced-fit.

Journal: Biochimie

Published: April 15, 2024

2,2'-Bithiophene as sensor tag for ligand-protein binding assays based on Förster resonance energy transfer.

2,2'-Bithiophene as sensor tag for ligand-protein binding assays based on Förster resonance energy transfer.

Journal: Analytical biochemistry

Published: August 07, 2023

N-sulfonyl peptide-hybrids as a new class of dengue virus protease inhibitors.

N-sulfonyl peptide-hybrids as a new class of dengue virus protease inhibitors.

Journal: European journal of medicinal chemistry

Published: December 07, 2022

Corona versus Dengue: Distinct Mechanisms for Inhibition of Polyprotein Processing by Antiviral Drugs.

Corona versus Dengue: Distinct Mechanisms for Inhibition of Polyprotein Processing by Antiviral Drugs.

Journal: ACS pharmacology & translational science

Published: July 15, 2022

Discovery of potent benzoxaborole inhibitors against SARS-CoV-2 main and dengue virus proteases.

Discovery of potent benzoxaborole inhibitors against SARS-CoV-2 main and dengue virus proteases.

Journal: European journal of medicinal chemistry

Published: April 07, 2022

On track to tackle dengue: History and future of NS4B ligands.

On track to tackle dengue: History and future of NS4B ligands.

Journal: Cell host & microbe

Published: December 09, 2021

The spectrum between substrates and inhibitors: Pinpointing the binding mode of dengue protease ligands with modulated basicity and hydrophobicity.

The spectrum between substrates and inhibitors: Pinpointing the binding mode of dengue protease ligands with modulated basicity and hydrophobicity.

Journal: Bioorganic & medicinal chemistry

Published: July 07, 2021

Efficiency Improvements and Discovery of New Substrates for a SARS-CoV-2 Main Protease FRET Assay.

Efficiency Improvements and Discovery of New Substrates for a SARS-CoV-2 Main Protease FRET Assay.

Journal: SLAS discovery : advancing life sciences R & D

Published: June 21, 2021

Showing 1-12 of 54

Last Updated: 09/26/2026