Christian Landles

London, ENG WC1N3BG, United Kingdom

Last Updated: 09/26/2026

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Found 25 publications

Blocking somatic repeat expansion and lowering huntingtin by RNAi synergize to attenuate Huntington's disease pathogenesis in mice.

Blocking somatic repeat expansion and lowering huntingtin by RNAi synergize to attenuate Huntington's disease pathogenesis in mice.

Journal: Science translational medicine

Published: August 12, 2026

Selective targeting of mutant huntingtin intron 1 improves rescue provided by antisense oligonucleotides in Huntington's disease mice.

Selective targeting of mutant huntingtin intron 1 improves rescue provided by antisense oligonucleotides in Huntington's disease mice.

Journal: Science translational medicine

Published: March 18, 2026

Lowering the HTT1a transcript as an effective therapy for Huntington's disease in a knockin mouse model.

Lowering the HTT1a transcript as an effective therapy for Huntington's disease in a knockin mouse model.

Journal: Science translational medicine

Published: March 18, 2026

Enhancing the detection of HTT1a with neoepitope antibodies in mouse models of Huntington's disease.

Enhancing the detection of HTT1a with neoepitope antibodies in mouse models of Huntington's disease.

Journal: Brain communications

Published: February 10, 2026

Molecular features of a Huntington's disease knock-in minipig.

Molecular features of a Huntington's disease knock-in minipig.

Journal: Disease models & mechanisms

Published: December 17, 2025

The HTT1a protein initiates HTT aggregation in a knock-in mouse model of Huntington's disease.

The HTT1a protein initiates HTT aggregation in a knock-in mouse model of Huntington's disease.

Journal: Brain : a journal of neurology

Published: September 19, 2025

Human-specific sequence features in HTT exon 1 promote toxic misprocessing via splicing factor SRSF7.

Human-specific sequence features in HTT exon 1 promote toxic misprocessing via splicing factor SRSF7.

Journal: Nature communications

Published: August 14, 2025

Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntington's disease pathogenesis in mice.

Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntington's disease pathogenesis in mice.

Journal: bioRxiv : the preprint server for biology

Published: July 16, 2025

Mutant huntingtin protein decreases with CAG repeat expansion: implications for therapeutics and bioassays.

Mutant huntingtin protein decreases with CAG repeat expansion: implications for therapeutics and bioassays.

Journal: Brain communications

Published: June 10, 2024

Exon 1-targeting miRNA reduces the pathogenic exon 1 HTT protein in Huntington's disease models.

Exon 1-targeting miRNA reduces the pathogenic exon 1 HTT protein in Huntington's disease models.

Journal: Brain : a journal of neurology

Published: December 07, 2023

A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease.

A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease.

Journal: Brain : a journal of neurology

Published: December 01, 2023

Early detection of exon 1 huntingtin aggregation in zQ175 brains by molecular and histological approaches.

Early detection of exon 1 huntingtin aggregation in zQ175 brains by molecular and histological approaches.

Journal: Brain communications

Published: September 01, 2022

Showing 1-12 of 25

Last Updated: 09/26/2026