Christina R. Tysoe

2036 Main Mall
Vancouver, BC V6T1Z1, Canada

Last Updated: 09/26/2026

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Found 18 publications

Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C-5a-Substituted Derivatives of 4-epi-Isofagomine.

Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C-5a-Substituted Derivatives of 4-epi-Isofagomine.

Journal: Molecules (Basel, Switzerland)

Published: July 29, 2020

Folding Then Binding vs Folding Through Binding in Macrocyclic Peptide Inhibitors of Human Pancreatic α-Amylase.

Folding Then Binding vs Folding Through Binding in Macrocyclic Peptide Inhibitors of Human Pancreatic α-Amylase.

Journal: ACS chemical biology

Published: June 27, 2019

Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic α-amylase.

Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic α-amylase.

Journal: Chemical science

Published: May 29, 2019

Structural Dissection of Helianthamide Reveals the Basis of Its Potent Inhibition of Human Pancreatic α-Amylase.

Structural Dissection of Helianthamide Reveals the Basis of Its Potent Inhibition of Human Pancreatic α-Amylase.

Journal: Biochemistry

Published: September 06, 2018

A new type of pharmacological chaperone for GM1-gangliosidosis related human lysosomal β-galactosidase: N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols.

A new type of pharmacological chaperone for GM1-gangliosidosis related human lysosomal β-galactosidase: N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols.

Journal: Bioorganic & medicinal chemistry letters

Published: March 15, 2017

A Morita-Baylis-Hillman based route to C-5a-chain-extended 4-epi-isofagomine type glycosidase inhibitors.

A Morita-Baylis-Hillman based route to C-5a-chain-extended 4-epi-isofagomine type glycosidase inhibitors.

Journal: Carbohydrate research

Published: February 09, 2017

N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols: A new family of activity promotors for a GM1-gangliosidosis related human lysosomal β-galactosidase mutant.

N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols: A new family of activity promotors for a GM1-gangliosidosis related human lysosomal β-galactosidase mutant.

Journal: Carbohydrate research

Published: February 02, 2017

C-5a-substituted validamine type glycosidase inhibitors.

C-5a-substituted validamine type glycosidase inhibitors.

Journal: Carbohydrate research

Published: November 30, 2016

Rapid Discovery of Potent and Selective Glycosidase-Inhibiting De Novo Peptides.

Rapid Discovery of Potent and Selective Glycosidase-Inhibiting De Novo Peptides.

Journal: Cell chemical biology

Published: October 09, 2016

Fungal Glycolipid Hydrolase Inhibitors and Their Effect on Cryptococcus neoformans.

Fungal Glycolipid Hydrolase Inhibitors and Their Effect on Cryptococcus neoformans.

Journal: Chembiochem : a European journal of chemical biology

Published: October 04, 2016

Glycosynthase mediated synthesis of psychosine.

Glycosynthase mediated synthesis of psychosine.

Journal: Carbohydrate research

Published: August 12, 2016

Synthesis of C-5a-substituted derivatives of 4-epi-isofagomine: notable β-galactosidase inhibitors and activity promotors of GM1-gangliosidosis related human lysosomal β-galactosidase mutant R201C.

Synthesis of C-5a-substituted derivatives of 4-epi-isofagomine: notable β-galactosidase inhibitors and activity promotors of GM1-gangliosidosis related human lysosomal β-galactosidase mutant R201C.

Journal: Carbohydrate research

Published: February 08, 2016

Showing 1-12 of 18

Last Updated: 09/26/2026