Christine A. Penfold

Southampton, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 17 publications

Gas-phase unfolding assay rapidly predicts structure-function relationships in engineered antibodies with tuned flexibilities.

Gas-phase unfolding assay rapidly predicts structure-function relationships in engineered antibodies with tuned flexibilities.

Journal: Nature communications

Published: August 22, 2025

Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism.

Structure-guided disulfide engineering restricts antibody conformation to elicit TNFR agonism.

Journal: Nature communications

Published: July 23, 2024

Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility.

Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility.

Journal: Science immunology

Published: July 20, 2022

Reducing affinity as a strategy to boost immunomodulatory antibody agonism.

Reducing affinity as a strategy to boost immunomodulatory antibody agonism.

Journal: Nature

Published: February 22, 2022

FcγRIIB controls antibody-mediated target cell depletion by ITIM-independent mechanisms.

FcγRIIB controls antibody-mediated target cell depletion by ITIM-independent mechanisms.

Journal: Cell reports

Published: February 20, 2022

Fc-null anti-PD-1 monoclonal antibodies deliver optimal checkpoint blockade in diverse immune environments.

Fc-null anti-PD-1 monoclonal antibodies deliver optimal checkpoint blockade in diverse immune environments.

Journal: Journal for immunotherapy of cancer

Published: December 08, 2021

Agonistic CD27 antibody potency is determined by epitope-dependent receptor clustering augmented through Fc-engineering.

Agonistic CD27 antibody potency is determined by epitope-dependent receptor clustering augmented through Fc-engineering.

Journal: Communications biology

Published: October 07, 2021

TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity.

TNF receptor agonists induce distinct receptor clusters to mediate differential agonistic activity.

Journal: Communications biology

Published: February 05, 2021

Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity.

Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity.

Journal: Cancer cell

Published: October 28, 2019

Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies.

Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies.

Journal: Cancer cell

Published: October 24, 2017

PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8+ T-Cell-Driven Antitumor Immunity.

PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8+ T-Cell-Driven Antitumor Immunity.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research

Published: October 16, 2017

Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function.

Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function.

Journal: Immunity

Published: August 14, 2017

Showing 1-12 of 17

Last Updated: 09/26/2026