Christine Helsen - Publications

Rewiring Estrogen Receptor α into Bisphenol Selective Receptors Using Darwin Assembly-Based Directed Evolution (DADE) in Saccharomyces cerevisiae.

Journal: ACS synthetic biology

Published: May 10, 2025

Case Report: A first case of desmin-related myofibrillar myopathy due to inheritance from a confirmed mosaic asymptomatic carrier.

Journal: Frontiers in genetics

Published: March 21, 2025

Genetic variants associated with ventricular arrhythmias during ajmaline test in Brugada syndrome.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

Published: March 03, 2025

Structural mechanism underlying variations in DNA binding by the androgen receptor.

Journal: The Journal of steroid biochemistry and molecular biology

Published: January 25, 2024

Discovery of a novel androgen receptor antagonist, MEL-6, with stereoselective activity and optimization of its metabolic stability.

Journal: The Journal of steroid biochemistry and molecular biology

Published: December 12, 2023

Rational evolution for altering the ligand preference of estrogen receptor alpha.

Journal: Protein science : a publication of the Protein Society

Published: November 02, 2023

Study of novel androgen receptor V770 variant in androgen insensitivity syndrome patients reveals the transitional state of the androgen receptor ligand binding domain homodimer.

Journal: Protein science : a publication of the Protein Society

Published: December 22, 2022

Editorial: Sexual dimorphism in biomedical research and its therapeutic implications.

Journal: Frontiers in endocrinology

Published: August 02, 2022

N/C Interactions Are Dispensable for Normal In Vivo Functioning of the Androgen Receptor in Male Mice.

Journal: Endocrinology

Published: May 16, 2022

Exploiting Ligand-binding Domain Dimerization for Development of Novel Androgen Receptor Inhibitors.

Journal: Molecular cancer therapeutics

Published: May 15, 2022

The T850D Phosphomimetic Mutation in the Androgen Receptor Ligand Binding Domain Enhances Recruitment at Activation Function 2.

Journal: International journal of molecular sciences

Published: December 11, 2021

Small-molecule profiling for steroid receptor activity using a universal steroid receptor reporter assay.

Journal: The Journal of steroid biochemistry and molecular biology

Published: October 11, 2021