Christoph Thiel
Aachen, NW, Germany
Last Updated: 09/26/2026
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Found 11 publications
A Model-Based Workflow to Benchmark the Clinical Cholestasis Risk of Drugs.
Journal: Clinical pharmacology and therapeutics
Published: February 23, 2021
Network integration and modelling of dynamic drug responses at multi-omics levels.
Journal: Communications biology
Published: February 17, 2020
A 3D Heterotypic Multicellular Tumor Spheroid Assay Platform to Discriminate Drug Effects on Stroma versus Cancer Cells.
Journal: SLAS discovery : advancing life sciences R & D
Published: October 30, 2019
A Physiology-Based Model of Human Bile Acid Metabolism for Predicting Bile Acid Tissue Levels After Drug Administration in Healthy Subjects and BRIC Type 2 Patients.
Journal: Frontiers in physiology
Published: February 18, 2019
Using quantitative systems pharmacology to evaluate the drug efficacy of COX-2 and 5-LOX inhibitors in therapeutic situations.
Journal: NPJ systems biology and applications
Published: October 16, 2017
Integration of genome-scale metabolic networks into whole-body PBPK models shows phenotype-specific cases of drug-induced metabolic perturbation.
Journal: NPJ systems biology and applications
Published: September 26, 2017
A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity.
Journal: Archives of toxicology
Published: July 14, 2017
A Comparative Analysis of Drug-Induced Hepatotoxicity in Clinically Relevant Situations.
Journal: PLoS computational biology
Published: October 06, 2016
A Physiologically Based Pharmacokinetic Model of Isoniazid and Its Application in Individualizing Tuberculosis Chemotherapy.
Journal: Antimicrobial agents and chemotherapy
Published: March 05, 2016
Model-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients.
Journal: Archives of toxicology
Published: January 28, 2016
A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation.
Journal: Journal of pharmaceutical sciences
Published: July 21, 2014
Showing 1-11 of 11
Last Updated: 09/26/2026