Christophe Orvain
Strasbourg, France
Last Updated: 09/26/2026
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Found 17 publications
In vitro screening of compounds for targeting gastric cancer with Y220C p53 mutation: a molecule combining zinc chelation and a Michael acceptor drives CDKN1 and BBC3 expression to restore a p53-dependent cytotoxicity.
Journal: Journal of enzyme inhibition and medicinal chemistry
Published: May 21, 2026
Evaluation of dual-function molecules containing both Zn-Ionophore and aggregation inhibition moieties for mutant p53 protein reactivation.
Journal: Journal of inorganic biochemistry
Published: July 04, 2025
Protoporphyrin IX-Derived Ruthenium(II) Complexes for Photodynamic Therapy in Gastric Cancer Cells.
Journal: Inorganic chemistry
Published: May 02, 2025
Platinum(II) and ruthenium(II) coordination complexes equipped with an anchoring site for binding the protein kinase enzyme pockets: synthesis, molecular docking and biological assays.
Journal: Dalton transactions (Cambridge, England : 2003)
Published: April 17, 2025
Quest for a stable Cu-ligand complex with a high catalytic activity to produce reactive oxygen species.
Journal: Metallomics : integrated biometal science
Published: March 21, 2024
The unfolded protein response-glutathione metabolism axis: A novel target of a cycloruthenated complexes bypassing tumor resistance mechanisms.
Journal: Cancer letters
Published: October 13, 2023
Altering relative metal-binding affinities in multifunctional Metallochaperones for mutant p53 reactivation.
Journal: Journal of inorganic biochemistry
Published: October 07, 2023
Multifunctional metallochaperone modifications for targeting subsite cavities in mutant p53-Y220C.
Journal: Journal of inorganic biochemistry
Published: January 24, 2023
Gold(III) to Ruthenium(III) Metal Exchange in Dithiocarbamato Complexes Tunes Their Biological Mode of Action for Cytotoxicity in Cancer Cells.
Journal: Molecules (Basel, Switzerland)
Published: May 27, 2021
HDAC4 Levels Control Sensibility toward Cisplatin in Gastric Cancer via the p53-p73/BIK Pathway.
Journal: Cancers
Published: September 05, 2019
Bifunctional ligand design for modulating mutant p53 aggregation in cancer.
Journal: Chemical science
Published: August 20, 2019
Last Updated: 09/26/2026