Christopher B. Marshall

Toronto, ON M5G1L7, Canada

Last Updated: 09/26/2026

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Found 41 publications

Switch II Pocket Inhibitor Allosterically Freezes KRASG12D Nucleotide-binding Site and Arrests the GTPase Cycle.

Switch II Pocket Inhibitor Allosterically Freezes KRASG12D Nucleotide-binding Site and Arrests the GTPase Cycle.

Journal: Journal of molecular biology

Published: February 17, 2025

DIRAS3-derived cyclic peptides disrupt KRAS-RAF interaction and KRAS nanoclustering, suppressing KRAS-driven pancreatic and ovarian tumors.

DIRAS3-derived cyclic peptides disrupt KRAS-RAF interaction and KRAS nanoclustering, suppressing KRAS-driven pancreatic and ovarian tumors.

Journal: iScience

Published: January 21, 2025

Crystal structure of NRAS Q61K with a ligand-induced pocket near switch II.

Crystal structure of NRAS Q61K with a ligand-induced pocket near switch II.

Journal: European journal of cell biology

Published: January 17, 2024

Reconstitution and characterization of BRAF in complex with 14-3-3 and KRAS4B on nanodiscs.

Reconstitution and characterization of BRAF in complex with 14-3-3 and KRAS4B on nanodiscs.

Journal: Protein science : a publication of the Protein Society

Published: December 21, 2023

Biochemical and biophysical characterization of the RAS family small GTPase protein DiRAS3.

Biochemical and biophysical characterization of the RAS family small GTPase protein DiRAS3.

Journal: Protein expression and purification

Published: July 25, 2023

The Self-Association of the KRAS4b Protein is Altered by Lipid-Bilayer Composition and Electrostatics.

The Self-Association of the KRAS4b Protein is Altered by Lipid-Bilayer Composition and Electrostatics.

Journal: Angewandte Chemie (International ed. in English)

Published: December 18, 2022

Hitting the hotspots.

Hitting the hotspots.

Journal: Nature chemical biology

Published: March 22, 2022

Structures of RGL1 RAS-Association Domain in Complex with KRAS and the Oncogenic G12V Mutant.

Structures of RGL1 RAS-Association Domain in Complex with KRAS and the Oncogenic G12V Mutant.

Journal: Journal of molecular biology

Published: September 30, 2021

Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization.

Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization.

Journal: Chemical science

Published: June 25, 2021

Regulation of GTPase function by autophosphorylation.

Regulation of GTPase function by autophosphorylation.

Journal: Molecular cell

Published: May 12, 2021

Lung Cancer Driven by BRAFG469V Mutation Is Targetable by EGFR Kinase Inhibitors.

Lung Cancer Driven by BRAFG469V Mutation Is Targetable by EGFR Kinase Inhibitors.

Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

Published: December 24, 2020

Nanoluciferase complementation-based bioreporter reveals the importance of N-linked glycosylation of SARS-CoV-2 S for viral entry.

Nanoluciferase complementation-based bioreporter reveals the importance of N-linked glycosylation of SARS-CoV-2 S for viral entry.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy

Published: November 17, 2020

Showing 1-12 of 41

Last Updated: 09/26/2026