Christopher G. Mowat

David Brewster Road
Edinburgh, SCT EH93FJ, United Kingdom

Last Updated: 09/26/2026

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Found 13 publications

Binding of l-kynurenine to X. campestris tryptophan 2,3-dioxygenase.

Binding of l-kynurenine to X. campestris tryptophan 2,3-dioxygenase.

Journal: Journal of inorganic biochemistry

Published: July 28, 2021

Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.

Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.

Journal: Journal of medicinal chemistry

Published: April 12, 2017

The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.

The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.

Journal: Bioorganic & medicinal chemistry letters

Published: January 09, 2017

Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase.

Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase.

Journal: Nature communications

Published: January 07, 2017

Insights into the mechanism of inhibition of tryptophan 2,3-dioxygenase by isatin derivatives.

Insights into the mechanism of inhibition of tryptophan 2,3-dioxygenase by isatin derivatives.

Journal: Journal of enzyme inhibition and medicinal chemistry

Published: April 21, 2016

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.

Journal: Nature medicine

Published: September 12, 2015

Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1.

Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1.

Journal: Amino acids

Published: November 07, 2013

Antitumour agents as inhibitors of tryptophan 2,3-dioxygenase.

Antitumour agents as inhibitors of tryptophan 2,3-dioxygenase.

Journal: Biochemical and biophysical research communications

Published: November 05, 2013

How is the distal pocket of a heme protein optimized for binding of tryptophan?

How is the distal pocket of a heme protein optimized for binding of tryptophan?

Journal: The FEBS journal

Published: September 17, 2012

Oxygen activation in neuronal NO synthase: resolving the consecutive mono-oxygenation steps.

Oxygen activation in neuronal NO synthase: resolving the consecutive mono-oxygenation steps.

Journal: The Biochemical journal

Published: February 04, 2012

Heme-containing dioxygenases involved in tryptophan oxidation.

Heme-containing dioxygenases involved in tryptophan oxidation.

Journal: Current opinion in chemical biology

Published: November 07, 2011

Flavin-containing heme enzymes.

Flavin-containing heme enzymes.

Journal: Archives of biochemistry and biophysics

Published: September 22, 2009

Showing 1-12 of 13

Last Updated: 09/26/2026