Christopher J. Smedley

Science Dr, Bundoora
Melbourne, VIC 3086, Australia

Last Updated: 09/26/2026

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Found 18 publications

Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium.

Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium.

Journal: bioRxiv : the preprint server for biology
Published: March 27, 2026

Structure-Activity Relationships of Highly Potent and Selective A2B Adenosine Receptor Agonists.

Structure-Activity Relationships of Highly Potent and Selective A2B Adenosine Receptor Agonists.

Journal: Journal of medicinal chemistry
Published: October 23, 2025

Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium.

Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium.

Journal: Nature communications
Published: October 01, 2025

The Synthesis of Sulfonyl Fluoride Functionalized 2-Aminothiazoles Using a Diversity Oriented Clicking Strategy.

The Synthesis of Sulfonyl Fluoride Functionalized 2-Aminothiazoles Using a Diversity Oriented Clicking Strategy.

Journal: Organic letters
Published: December 16, 2024

Phosphorus fluoride exchange: Multidimensional catalytic click chemistry from phosphorus connective hubs.

Phosphorus fluoride exchange: Multidimensional catalytic click chemistry from phosphorus connective hubs.

Journal: Chem
Published: June 17, 2024

Ethene-1,1-disulfonyl Difluoride (EDSF) for SuFEx Click Chemistry: Synthesis of SuFExable 1,1-Bissulfonylfluoride Substituted Cyclobutene Hubs.

Ethene-1,1-disulfonyl Difluoride (EDSF) for SuFEx Click Chemistry: Synthesis of SuFExable 1,1-Bissulfonylfluoride Substituted Cyclobutene Hubs.

Journal: Angewandte Chemie (International ed. in English)
Published: March 17, 2023

A diversity oriented clicking strategy: the stereoselective synthesis of highly-functionalised olefins from 2-substituted-alkynyl-1-sulfonyl fluorides.

A diversity oriented clicking strategy: the stereoselective synthesis of highly-functionalised olefins from 2-substituted-alkynyl-1-sulfonyl fluorides.

Journal: Chemical communications (Cambridge, England)
Published: September 21, 2022

Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors.

Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors.

Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: September 07, 2022

Accelerated SuFEx Click Chemistry For Modular Synthesis.

Accelerated SuFEx Click Chemistry For Modular Synthesis.

Journal: Angewandte Chemie (International ed. in English)
Published: September 11, 2021

Aminium cation-radical catalysed selective hydration of (E)-aryl enynes.

Aminium cation-radical catalysed selective hydration of (E)-aryl enynes.

Journal: Chemical communications (Cambridge, England)
Published: June 23, 2021

Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2-Substituted-Alkynyl-1-Sulfonyl Fluoride (SASF) Hubs.

Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2-Substituted-Alkynyl-1-Sulfonyl Fluoride (SASF) Hubs.

Journal: Angewandte Chemie (International ed. in English)
Published: March 02, 2020

Metal-Free Synthesis of Functional 1-Substituted-1,2,3-Triazoles from Ethenesulfonyl Fluoride and Organic Azides.

Metal-Free Synthesis of Functional 1-Substituted-1,2,3-Triazoles from Ethenesulfonyl Fluoride and Organic Azides.

Journal: Angewandte Chemie (International ed. in English)
Published: October 05, 2019
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Last Updated: 09/26/2026