Christopher N. Toepfer

Oxford, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 36 publications

Targeting Inflammation by Pioglitazone and its R-Enantiomer Mitigates Pathological Myocardial Remodeling in Murine Hypertrophic Cardiomyopathy.

Targeting Inflammation by Pioglitazone and its R-Enantiomer Mitigates Pathological Myocardial Remodeling in Murine Hypertrophic Cardiomyopathy.

Journal: JACC. Basic to translational science
Published: February 13, 2026

Desmoglein-2 deficiency results in cardiac dysfunction by compromising both Z-disc- and intercalated disc-mediated mechanotransduction.

Desmoglein-2 deficiency results in cardiac dysfunction by compromising both Z-disc- and intercalated disc-mediated mechanotransduction.

Journal: bioRxiv : the preprint server for biology
Published: November 19, 2025

Transcriptional and functional effects of mavacamten in multiple porcine and human models with hypertrophic cardiomyopathy.

Transcriptional and functional effects of mavacamten in multiple porcine and human models with hypertrophic cardiomyopathy.

Journal: British journal of pharmacology
Published: May 23, 2025

Microscale droplet assembly enables biocompatible multifunctional modular iontronics.

Microscale droplet assembly enables biocompatible multifunctional modular iontronics.

Journal: Science (New York, N.Y.)
Published: November 28, 2024

Hypertrophic cardiomyopathy-associated mutations drive stromal activation via EGFR-mediated paracrine signaling.

Hypertrophic cardiomyopathy-associated mutations drive stromal activation via EGFR-mediated paracrine signaling.

Journal: Science advances
Published: October 16, 2024

An ALPK3 truncation variant causing autosomal dominant hypertrophic cardiomyopathy is partially rescued by mavacamten.

An ALPK3 truncation variant causing autosomal dominant hypertrophic cardiomyopathy is partially rescued by mavacamten.

Journal: Scientific reports
Published: October 09, 2024

Assaying the myosin super-relaxed state across muscle types, cells and proteins for understanding muscle biology and use in drug discovery.

Assaying the myosin super-relaxed state across muscle types, cells and proteins for understanding muscle biology and use in drug discovery.

Journal: Nature protocols
Published: June 07, 2024

Regulation of sarcomere formation and function in the healthy heart requires a titin intronic enhancer.

Regulation of sarcomere formation and function in the healthy heart requires a titin intronic enhancer.

Journal: The Journal of clinical investigation
Published: June 04, 2024

Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy.

Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy.

Journal: Scientific reports
Published: May 06, 2024

Mechanisms of Pathogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant R278C+/- During Development.

Mechanisms of Pathogenicity of Hypertrophic Cardiomyopathy-Associated Troponin T (TNNT2) Variant R278C+/- During Development.

Journal: bioRxiv : the preprint server for biology
Published: August 23, 2023

Comparing the effects of chemical Ca2+ dyes and R-GECO on contractility and Ca2+ transients in adult and human iPSC cardiomyocytes.

Comparing the effects of chemical Ca2+ dyes and R-GECO on contractility and Ca2+ transients in adult and human iPSC cardiomyocytes.

Journal: Journal of molecular and cellular cardiology
Published: November 25, 2022

Cardiomyocyte infection by Trypanosoma cruzi promotes innate immune response and glycolysis activation.

Cardiomyocyte infection by Trypanosoma cruzi promotes innate immune response and glycolysis activation.

Journal: Frontiers in cellular and infection microbiology
Published: November 14, 2022
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Last Updated: 09/26/2026