Christopher P. Webster
385 Glossop Road
Sheffield, ENG, United Kingdom
Sheffield, ENG, United Kingdom
Last Updated: 09/26/2026
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Found 18 publications
Antisense Dipeptide Repeat Proteins Drive Widescale Purine Metabolism Aberration in C9orf72 Amyotrophic Lateral Sclerosis via ADA.
Journal: International journal of molecular sciences
Published: January 25, 2026
RuvBL1/2 reduce toxic dipeptide repeat protein burden in multiple models of C9orf72-ALS/FTD.
Journal: Life science alliance
Published: April 05, 2024
Pre-clinical development of AP4B1 gene replacement therapy for hereditary spastic paraplegia type 47.
Journal: EMBO molecular medicine
Published: March 15, 2024
A systematic review of immunosuppressive protocols used in AAV gene therapy for monogenic disorders.
A systematic review of immunosuppressive protocols used in AAV gene therapy for monogenic disorders.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy
Published: February 06, 2024
Editorial: Advanced (gene and cell) therapies for central nervous system applications.
Journal: Frontiers in molecular neuroscience
Published: January 09, 2023
Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation.
Journal: Frontiers in cellular neuroscience
Published: October 04, 2022
Ap4b1-knockout mouse model of hereditary spastic paraplegia type 47 displays motor dysfunction, aberrant brain morphology and ATG9A mislocalization.
Journal: Brain communications
Published: May 09, 2022
An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD.
Journal: Acta neuropathologica
Published: February 25, 2022
SPG15 protein deficits are at the crossroads between lysosomal abnormalities, altered lipid metabolism and synaptic dysfunction.
Journal: Human molecular genetics
Published: January 09, 2022
C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons.
Journal: Life science alliance
Published: October 26, 2021
SMN-deficient cells exhibit increased ribosomal DNA damage.
Journal: Life science alliance
Published: June 28, 2021
The hybrid AAVP tool gets an upgrade.
Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: August 25, 2019
Last Updated: 09/26/2026