Christopher T. Lemke

2100 Cunard Street
Laval, QC H7S2G5, Canada

Last Updated: 09/26/2026

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Found 14 publications

Ligand bioactive conformation plays a critical role in the design of drugs that target the hepatitis C virus NS3 protease.

Ligand bioactive conformation plays a critical role in the design of drugs that target the hepatitis C virus NS3 protease.

Journal: Journal of medicinal chemistry

Published: October 23, 2013

Enantiomeric atropisomers inhibit HCV polymerase and/or HIV matrix: characterizing hindered bond rotations and target selectivity.

Enantiomeric atropisomers inhibit HCV polymerase and/or HIV matrix: characterizing hindered bond rotations and target selectivity.

Journal: Journal of medicinal chemistry

Published: September 13, 2013

Discovery of novel small-molecule HIV-1 replication inhibitors that stabilize capsid complexes.

Discovery of novel small-molecule HIV-1 replication inhibitors that stabilize capsid complexes.

Journal: Antimicrobial agents and chemotherapy

Published: July 03, 2013

Discovery of novel P2 substituted 4-biaryl proline inhibitors of hepatitis C virus NS3 serine protease.

Discovery of novel P2 substituted 4-biaryl proline inhibitors of hepatitis C virus NS3 serine protease.

Journal: Bioorganic & medicinal chemistry letters

Published: March 25, 2013

Novel inhibitor binding site discovery on HIV-1 capsid N-terminal domain by NMR and X-ray crystallography.

Novel inhibitor binding site discovery on HIV-1 capsid N-terminal domain by NMR and X-ray crystallography.

Journal: ACS chemical biology

Published: March 19, 2013

Peptide backbone replacement of hepatitis C virus NS3 serine protease C-terminal cleavage product analogs: discovery of potent succinamide inhibitors.

Peptide backbone replacement of hepatitis C virus NS3 serine protease C-terminal cleavage product analogs: discovery of potent succinamide inhibitors.

Journal: Bioorganic & medicinal chemistry letters

Published: March 08, 2013

Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 2: structure-activity relationships (SAR) of the C3-phenyl moiety.

Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 2: structure-activity relationships (SAR) of the C3-phenyl moiety.

Journal: Bioorganic & medicinal chemistry letters

Published: February 08, 2013

Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 1: addressing configurational instability through scaffold modification.

Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 1: addressing configurational instability through scaffold modification.

Journal: Bioorganic & medicinal chemistry letters

Published: February 08, 2013

A novel inhibitor-binding site on the HIV-1 capsid N-terminal domain leads to improved crystallization via compound-mediated dimerization.

A novel inhibitor-binding site on the HIV-1 capsid N-terminal domain leads to improved crystallization via compound-mediated dimerization.

Journal: Acta crystallographica. Section D, Biological crystallography

Published: January 28, 2013

Synthesis and optimization of a novel series of HCV NS3 protease inhibitors: 4-arylproline analogs.

Synthesis and optimization of a novel series of HCV NS3 protease inhibitors: 4-arylproline analogs.

Journal: Bioorganic & medicinal chemistry letters

Published: January 25, 2013

Molecular mechanism by which a potent hepatitis C virus NS3-NS4A protease inhibitor overcomes emergence of resistance.

Molecular mechanism by which a potent hepatitis C virus NS3-NS4A protease inhibitor overcomes emergence of resistance.

Journal: The Journal of biological chemistry

Published: December 29, 2012

Monitoring binding of HIV-1 capsid assembly inhibitors using (19)F ligand-and (15)N protein-based NMR and X-ray crystallography: early hit validation of a benzodiazepine series.

Monitoring binding of HIV-1 capsid assembly inhibitors using (19)F ligand-and (15)N protein-based NMR and X-ray crystallography: early hit validation of a benzodiazepine series.

Journal: ChemMedChem

Published: December 17, 2012

Showing 1-12 of 14

Last Updated: 09/26/2026