Chu-yi Yu

Beijing, 100049, China

Last Updated: 09/26/2026

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Found 28 publications

4-Dehydroxymethyl-4-C-biphenyl-DAB derivatives: introduction of a biphenyl group at the C4 position shifts the binding selectivity, resulting in improved affinity for lysosomal acid β-glucocerebrosidase.

4-Dehydroxymethyl-4-C-biphenyl-DAB derivatives: introduction of a biphenyl group at the C4 position shifts the binding selectivity, resulting in improved affinity for lysosomal acid β-glucocerebrosidase.

Journal: Organic & biomolecular chemistry

Published: July 31, 2026

C-2 fluorinated castanospermines as potent and specific α-glucosidase inhibitors: synthesis and structure-activity relationship study.

C-2 fluorinated castanospermines as potent and specific α-glucosidase inhibitors: synthesis and structure-activity relationship study.

Journal: Organic & biomolecular chemistry

Published: February 20, 2025

Enantiomeric C-6 fluorinated swainsonine derivatives as highly selective and potent inhibitors of α-mannosidase and α-l-rhamnosidase: Design, synthesis and structure-activity relationship study.

Enantiomeric C-6 fluorinated swainsonine derivatives as highly selective and potent inhibitors of α-mannosidase and α-l-rhamnosidase: Design, synthesis and structure-activity relationship study.

Journal: European journal of medicinal chemistry

Published: August 13, 2024

Design and synthesis of 6-C-alkyl-DMDP type nanomolar inhibitors of β-galactosidase and β-glucosidase based on broussonetine S and related derivatives.

Design and synthesis of 6-C-alkyl-DMDP type nanomolar inhibitors of β-galactosidase and β-glucosidase based on broussonetine S and related derivatives.

Journal: European journal of medicinal chemistry

Published: April 26, 2024

Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity.

Cellular spermine targets JAK signaling to restrain cytokine-mediated autoimmunity.

Journal: Immunity

Published: April 13, 2023

Design and synthesis of iso-allo-DNJ and L-isoDALDP derivatives: pursuit of potent and selective inhibitors of α-glucosidase.

Design and synthesis of iso-allo-DNJ and L-isoDALDP derivatives: pursuit of potent and selective inhibitors of α-glucosidase.

Journal: Organic & biomolecular chemistry

Published: April 11, 2023

Design, synthesis and glycosidase inhibition of DAB derivatives with C-4 peptide and dipeptide branches.

Design, synthesis and glycosidase inhibition of DAB derivatives with C-4 peptide and dipeptide branches.

Journal: Organic & biomolecular chemistry

Published: March 14, 2023

C-6 fluorinated casuarines as highly potent and selective amyloglucosidase inhibitors: Synthesis and structure-activity relationship study.

C-6 fluorinated casuarines as highly potent and selective amyloglucosidase inhibitors: Synthesis and structure-activity relationship study.

Journal: European journal of medicinal chemistry

Published: August 30, 2022

Nanomolar β-glucosidase and β-galactosidase inhibition by enantiomeric α-1-C-alkyl-1,4-dideoxy-1,4-imino-arabinitol derivatives.

Nanomolar β-glucosidase and β-galactosidase inhibition by enantiomeric α-1-C-alkyl-1,4-dideoxy-1,4-imino-arabinitol derivatives.

Journal: European journal of medicinal chemistry

Published: August 17, 2022

Introduction of C-alkyl branches to L-iminosugars changes their active site binding orientation.

Introduction of C-alkyl branches to L-iminosugars changes their active site binding orientation.

Journal: Organic & biomolecular chemistry

Published: July 15, 2022

trans, trans-2-C-Aryl-3,4-dihydroxypyrrolidines as potent and selective β-glucosidase inhibitors: Pharmacological chaperones for Gaucher disease.

trans, trans-2-C-Aryl-3,4-dihydroxypyrrolidines as potent and selective β-glucosidase inhibitors: Pharmacological chaperones for Gaucher disease.

Journal: European journal of medicinal chemistry

Published: March 17, 2022

5-C-Branched Deoxynojirimycin: Strategy for Designing a 1-Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease.

5-C-Branched Deoxynojirimycin: Strategy for Designing a 1-Deoxynojirimycin-Based Pharmacological Chaperone with a Nanomolar Affinity for Pompe Disease.

Journal: Journal of medicinal chemistry

Published: January 24, 2022

Showing 1-12 of 28

Last Updated: 09/26/2026