Chuanliang Zhang

Qingdao Key Laboratory Of Biomacromolecular Drug Discovery And Development
Qingdao, 266042, China

Last Updated: 09/26/2026

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Found 9 publications

Design of potent, proteolytically stable stapled lipopeptide analogues of BimBH3 as PTP1B inhibitors for diabetes therapy.

Design of potent, proteolytically stable stapled lipopeptide analogues of BimBH3 as PTP1B inhibitors for diabetes therapy.

Journal: European journal of medicinal chemistry

Published: January 12, 2026

Dual Conjugation of Long- and Medium-Chain Fatty Acids to BimBH3 Peptide Yields Ultra Long-Acting Inhibitors of Intracellular PTPN1/2.

Dual Conjugation of Long- and Medium-Chain Fatty Acids to BimBH3 Peptide Yields Ultra Long-Acting Inhibitors of Intracellular PTPN1/2.

Journal: Journal of medicinal chemistry

Published: June 03, 2025

Glycosylation Modification Balances the Aqueous Solubility of Lipidated Peptides and Facilitates Their Biostability.

Glycosylation Modification Balances the Aqueous Solubility of Lipidated Peptides and Facilitates Their Biostability.

Journal: Bioconjugate chemistry

Published: April 09, 2025

Fatty acid conjugated BimBH3 analogues with d‑amino acid substitution as PTPN1 inhibitors with enhanced activity, biostability and orally available potency for the treatment of diabetes.

Fatty acid conjugated BimBH3 analogues with d‑amino acid substitution as PTPN1 inhibitors with enhanced activity, biostability and orally available potency for the treatment of diabetes.

Journal: Bioorganic & medicinal chemistry

Published: December 11, 2024

Site-Specifically Modified Peptide Inhibitors of Protein Tyrosine Phosphatase 1B and T-Cell Protein Tyrosine Phosphatase with Enhanced Stability and Improved In Vivo Long-Acting Activity.

Site-Specifically Modified Peptide Inhibitors of Protein Tyrosine Phosphatase 1B and T-Cell Protein Tyrosine Phosphatase with Enhanced Stability and Improved In Vivo Long-Acting Activity.

Journal: ACS pharmacology & translational science

Published: February 02, 2024

Discovery of Novel PTP1B Inhibitors with Once-Weekly Therapeutic Potential for Type 2 Diabetes: Design, Synthesis, and In Vitro and In Vivo Investigations of BimBH3 Peptide Analogues.

Discovery of Novel PTP1B Inhibitors with Once-Weekly Therapeutic Potential for Type 2 Diabetes: Design, Synthesis, and In Vitro and In Vivo Investigations of BimBH3 Peptide Analogues.

Journal: Journal of medicinal chemistry

Published: February 07, 2023

Discovery of Novel PTP1B Inhibitors Derived from the BH3 Domain of Proapoptotic Bcl-2 Proteins with Antidiabetic Potency.

Discovery of Novel PTP1B Inhibitors Derived from the BH3 Domain of Proapoptotic Bcl-2 Proteins with Antidiabetic Potency.

Journal: ACS medicinal chemistry letters

Published: March 29, 2021

A β-1,3/1,6-glucan from Durvillaea Antarctica inhibits tumor progression in vivo as an immune stimulator.

A β-1,3/1,6-glucan from Durvillaea Antarctica inhibits tumor progression in vivo as an immune stimulator.

Journal: Carbohydrate polymers

Published: March 27, 2019

BH3 mimetics derived from Bim-BH3 domain core region show PTP1B inhibitory activity.

BH3 mimetics derived from Bim-BH3 domain core region show PTP1B inhibitory activity.

Journal: Bioorganic & medicinal chemistry letters

Published: November 02, 2018

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Last Updated: 09/26/2026