Ciaran P. Fisher

Stevenage, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 31 publications

Quantitative systems toxicology approach that integrates PBPK and core hepatic metabolism: a case study with valproic acid.

Quantitative systems toxicology approach that integrates PBPK and core hepatic metabolism: a case study with valproic acid.

Journal: Frontiers in pharmacology

Published: December 15, 2025

Quantitative systems toxicology: modelling to mechanistically understand and predict drug safety.

Quantitative systems toxicology: modelling to mechanistically understand and predict drug safety.

Journal: Nature reviews. Drug discovery

Published: September 17, 2025

Response to "Acetaminophen should be a critical reference hepatotoxin for evaluating human-relevant in vitro models".

Response to "Acetaminophen should be a critical reference hepatotoxin for evaluating human-relevant in vitro models".

Journal: Toxicological sciences : an official journal of the Society of Toxicology

Published: December 26, 2024

Limitations of acetaminophen as a reference hepatotoxin for the evaluation of in vitro liver models.

Limitations of acetaminophen as a reference hepatotoxin for the evaluation of in vitro liver models.

Journal: Toxicological sciences : an official journal of the Society of Toxicology

Published: November 07, 2024

Spatio-temporal transcriptomic analysis reveals distinct nephrotoxicity, DNA damage, and regeneration response after cisplatin.

Spatio-temporal transcriptomic analysis reveals distinct nephrotoxicity, DNA damage, and regeneration response after cisplatin.

Journal: Cell biology and toxicology

Published: September 20, 2024

Utilizing rat kidney gene co-expression networks to enhance safety assessment biomarker identification and human translation.

Utilizing rat kidney gene co-expression networks to enhance safety assessment biomarker identification and human translation.

Journal: iScience

Published: May 07, 2024

Protectiveness of NAM-based hazard assessment - which testing scope is required?

Protectiveness of NAM-based hazard assessment - which testing scope is required?

Journal: ALTEX

Published: September 08, 2023

A systems approach reveals species differences in hepatic stress response capacity.

A systems approach reveals species differences in hepatic stress response capacity.

Journal: Toxicological sciences : an official journal of the Society of Toxicology

Published: August 30, 2023

The integrated stress response-related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability.

The integrated stress response-related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability.

Journal: Liver international : official journal of the International Association for the Study of the Liver

Published: April 06, 2023

SimRFlow: An R-based workflow for automated high-throughput PBPK simulation with the Simcyp® simulator.

SimRFlow: An R-based workflow for automated high-throughput PBPK simulation with the Simcyp® simulator.

Journal: Frontiers in pharmacology

Published: April 26, 2022

A Transcriptomic Approach to Elucidate the Mechanisms of Gefitinib-Induced Toxicity in Healthy Human Intestinal Organoids.

A Transcriptomic Approach to Elucidate the Mechanisms of Gefitinib-Induced Toxicity in Healthy Human Intestinal Organoids.

Journal: International journal of molecular sciences

Published: February 01, 2022

Unravelling Mechanisms of Doxorubicin-Induced Toxicity in 3D Human Intestinal Organoids.

Unravelling Mechanisms of Doxorubicin-Induced Toxicity in 3D Human Intestinal Organoids.

Journal: International journal of molecular sciences

Published: December 28, 2021

Showing 1-12 of 31

Last Updated: 09/26/2026