Claire Le Manach
University Of Cape Town
Rondebosch, WC 7701, South Africa
Rondebosch, WC 7701, South Africa
Last Updated: 09/26/2026
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Found 26 publications
Charting New Territory: Systematic Evaluation of the Drug Potential of N-Trifluoromethyl Amides, Ureas & Carbamates.
Journal: Journal of medicinal chemistry
Published: July 03, 2026
Evaluation of Oral PROTAC Guidelines: Efflux Ratio Outweighs Chameleonicity Descriptors.
Journal: ACS medicinal chemistry letters
Published: January 20, 2026
Cell-Based Progression of Spiroindoline Phenotypic Hits Leads to the Identification of Compounds with Diverging Parasitological Profiles against the Human Malaria Parasite Plasmodium falciparum.
Journal: Journal of medicinal chemistry
Published: May 12, 2025
Dose-fractionation studies of a Plasmodium phosphatidylinositol 4-kinase inhibitor in a humanized mouse model of malaria.
Journal: Antimicrobial agents and chemotherapy
Published: August 28, 2024
The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance.
Journal: Cell chemical biology
Published: April 06, 2021
Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts.
Journal: Journal of medicinal chemistry
Published: February 12, 2021
Correction to "Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model".
Journal: Journal of medicinal chemistry
Published: January 28, 2021
Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model.
Journal: Journal of medicinal chemistry
Published: October 26, 2020
Synthesis, Structure-Activity Relationship, and Mechanistic Studies of Aminoquinazolinones Displaying Antimycobacterial Activity.
Journal: ACS infectious diseases
Published: May 30, 2020
Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".
Journal: Antimicrobial agents and chemotherapy
Published: October 26, 2018
Antimalarial Lead-Optimization Studies on a 2,6-Imidazopyridine Series within a Constrained Chemical Space To Circumvent Atypical Dose-Response Curves against Multidrug Resistant Parasite Strains.
Journal: Journal of medicinal chemistry
Published: September 27, 2018
Last Updated: 09/26/2026