Clara C. Posthuma

Leiden, ZH 2333ZA, Netherlands

Last Updated: 09/26/2026

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Found 22 publications

Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in Betacoronavirus replication.

Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in Betacoronavirus replication.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: October 16, 2021

The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2.

The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2.

Journal: Journal of virology

Published: June 19, 2020

Design, Synthesis, and Anti-RNA Virus Activity of 6'-Fluorinated-Aristeromycin Analogues.

Design, Synthesis, and Anti-RNA Virus Activity of 6'-Fluorinated-Aristeromycin Analogues.

Journal: Journal of medicinal chemistry

Published: June 28, 2019

The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity.

The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity.

Journal: Frontiers in microbiology

Published: May 29, 2019

Adaptive Mutations in Replicase Transmembrane Subunits Can Counteract Inhibition of Equine Arteritis Virus RNA Synthesis by Cyclophilin Inhibitors.

Adaptive Mutations in Replicase Transmembrane Subunits Can Counteract Inhibition of Equine Arteritis Virus RNA Synthesis by Cyclophilin Inhibitors.

Journal: Journal of virology

Published: March 22, 2019

Cyclophilins and cyclophilin inhibitors in nidovirus replication.

Cyclophilins and cyclophilin inhibitors in nidovirus replication.

Journal: Virology

Published: May 11, 2018

Coronaviruses and arteriviruses display striking differences in their cyclophilin A-dependence during replication in cell culture.

Coronaviruses and arteriviruses display striking differences in their cyclophilin A-dependence during replication in cell culture.

Journal: Virology

Published: October 20, 2017

Inducing fluorescence of uranyl acetate as a dual-purpose contrast agent for correlative light-electron microscopy with nanometre precision.

Inducing fluorescence of uranyl acetate as a dual-purpose contrast agent for correlative light-electron microscopy with nanometre precision.

Journal: Scientific reports

Published: April 13, 2017

Nidovirus RNA polymerases: Complex enzymes handling exceptional RNA genomes.

Nidovirus RNA polymerases: Complex enzymes handling exceptional RNA genomes.

Journal: Virus research

Published: December 09, 2016

Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model.

Alisporivir inhibits MERS- and SARS-coronavirus replication in cell culture, but not SARS-coronavirus infection in a mouse model.

Journal: Virus research

Published: September 01, 2016

Arterivirus RNA-dependent RNA polymerase: Vital enzymatic activity remains elusive.

Arterivirus RNA-dependent RNA polymerase: Vital enzymatic activity remains elusive.

Journal: Virology

Published: July 07, 2015

Arterivirus nsp12 versus the coronavirus nsp16 2'-O-methyltransferase: comparison of the C-terminal cleavage products of two nidovirus pp1ab polyproteins.

Arterivirus nsp12 versus the coronavirus nsp16 2'-O-methyltransferase: comparison of the C-terminal cleavage products of two nidovirus pp1ab polyproteins.

Journal: The Journal of general virology

Published: June 05, 2015

Showing 1-12 of 22

Last Updated: 09/26/2026