Clemens Steegborn

Bayreuth, BY 95447, Germany

Last Updated: 09/26/2026

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Found 91 publications

Human Proteoglycan Linkage Region Glycosyltransferases are Dimeric and Show Unexpected Specificities.

Human Proteoglycan Linkage Region Glycosyltransferases are Dimeric and Show Unexpected Specificities.

Journal: Angewandte Chemie (International ed. in English)

Published: July 31, 2025

Updating the Mechanism of Bicarbonate (HCO3-) Activation of Soluble Adenylyl Cyclase (sAC).

Updating the Mechanism of Bicarbonate (HCO3-) Activation of Soluble Adenylyl Cyclase (sAC).

Journal: International journal of molecular sciences

Published: June 05, 2025

Potential 14-3-3 binding sites in sirtuins reveal extended phosphosite-recognition modes.

Potential 14-3-3 binding sites in sirtuins reveal extended phosphosite-recognition modes.

Journal: Acta crystallographica. Section F, Structural biology communications

Published: May 23, 2025

In silico-guided exploration of SIRT6 modulation: Discovery of new fragments hits inhibitors.

In silico-guided exploration of SIRT6 modulation: Discovery of new fragments hits inhibitors.

Journal: Journal of molecular graphics & modelling

Published: February 13, 2025

Structural Insights into the Iodothyronine Deiodinase 2 Catalytic Core and Deiodinase Catalysis and Dimerization.

Structural Insights into the Iodothyronine Deiodinase 2 Catalytic Core and Deiodinase Catalysis and Dimerization.

Journal: Biomolecules

Published: September 05, 2024

Elucidating the Unconventional Binding Mode of a DNA-Encoded Library Hit Provides a Blueprint for Sirtuin 6 Inhibitor Development.

Elucidating the Unconventional Binding Mode of a DNA-Encoded Library Hit Provides a Blueprint for Sirtuin 6 Inhibitor Development.

Journal: ChemMedChem

Published: April 16, 2024

Addition to "Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation".

Addition to "Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation".

Journal: Journal of chemical information and modeling

Published: January 23, 2024

Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity.

Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity.

Journal: Journal of medicinal chemistry

Published: January 22, 2024

Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells.

Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells.

Journal: Journal of medicinal chemistry

Published: July 13, 2023

SIRT6 Protects Against Lipopolysaccharide-Induced Inflammation in Human Pulmonary Lung Microvascular Endothelial Cells.

SIRT6 Protects Against Lipopolysaccharide-Induced Inflammation in Human Pulmonary Lung Microvascular Endothelial Cells.

Journal: Inflammation

Published: June 13, 2023

Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation.

Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation.

Journal: Journal of chemical information and modeling

Published: April 15, 2023

Corrigendum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential.

Corrigendum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential.

Journal: Frontiers in physiology

Published: February 10, 2023

Showing 1-12 of 91

Last Updated: 09/26/2026